ArticleScientific reports2015
Chronic Stress Alters Spatial Representation and Bursting Patterns of Place Cells in Behaving Mice.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Role of Hypothalamic CRH Neurons in Regulating the Impact of Stress on Memory and Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Inhibition of hippocampal or thalamic inputs to the nucleus accumbens reverses stress-induced alterations in dopamine system function.The international journal of neuropsychopharmacology · 2025Article
- Article
- A hypothalamic circuit mechanism underlying the impact of stress on memory and sleep.bioRxiv : the preprint server for biology · 2024Article
- Distinct Disruptions in CA1 and CA3 Place Cell Function in Alzheimer's Disease Mice.bioRxiv : the preprint server for biology · 2024Article
- The medial entorhinal cortex is necessary for the stimulus control over hippocampal place fields by distal, but not proximal, landmarks.Hippocampus · 2023Article
- Neurocognitive effects of stress: a metaparadigm perspective.Molecular psychiatry · 2023Review
- Biological embedding of early trauma: the role of higher prefrontal synaptic strength.European journal of psychotraumatology · 2023Article
- Repeated stress exposure leads to structural synaptic instability prior to disorganization of hippocampal coding and impairments in learning.Translational psychiatry · 2022Article
- Impaired Cognitive Flexibility Induced by Chronic Cerebral Hypoperfusion in the 5XFAD Transgenic Mouse Model of Mixed Dementia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Stress enhances hippocampal neuronal synchrony and alters ripple-spike interaction.Neurobiology of stress · 2021Article
- Characterization of Comorbid Posttraumatic Stress Disorder and Major Depressive Disorder Using Ketamine as an Experimental Medicine ProbeJournal of psychiatry and brain science · 2021Article
- The Involvement of Canonical Wnt Signaling in Memory Impairment Induced by Chronic Cerebral Hypoperfusion in Mice.Translational stroke research · 2020Article
- The Ventral Midline Thalamus Mediates Hippocampal Spatial Information Processes upon Spatial Cue Changes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Article
- Impaired Cognitive Performance in Endothelial Nitric Oxide Synthase Knockout Mice After Ischemic Stroke: A Pilot Study.American journal of physical medicine & rehabilitation · 2018Article
- Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic.Current psychiatry reports · 2017Review
- Unpredictable chronic mild stress differentially impairs social and contextual discrimination learning in two inbred mouse strains.PloS one · 2017Article
- Conditional Knockout of Cav2.1 Disrupts the Accuracy of Spatial Recognition of CA1 Place Cells and Spatial/Contextual Recognition Behavior.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Chronic uncontrollable stress has been shown to produce various physiological alterations and impair mnemonic functions in the rodent hippocampus. Impacts on neuronal activities, however, have not been well investigated. The present study examined dorsal CA1 place cells to elucidate the computational changes associated with chronic stress effects on cognitive behaviors. After administering chronic restraint stress (CRS; 6 hours/day for ≥21 consecutive days) to adult male mice, several hippocampal characteristics were examined; i.e., spatial learning, in vitro synaptic plasticity, in vivo place cell recording, and western blot analysis to determine protein levels related to learning and memory. Behaviorally, CRS significantly impeded spatial learning but enhanced non-spatial cue learning on the Morris water maze. Physiologically, CRS reduced long-term potentiation (LTP) of Schaffer collateral/commisural-CA1 pathway, phospho-αCaMKII (alpha Ca2(+)/calmodulin-dependent protein kinase II) level in the hippocampus, and stability of spatial representation and the mean firing rates (FRs) of place cells. Moreover, the local cue-dependency of place fields was increased, and the intra-burst interval (IntraBI) between consecutive spikes within a burst was prolonged following CRS. These results extend the previous findings of stress impairing LTP and spatial learning to CRS modifying physical properties of spiking in place cells that contribute to changes in navigation and synaptic plasticity.
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