ArticleScientific reports2015
The role of H4 flagella in Escherichia coli ST131 virulence.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Global High-RiskInternational journal of microbiology · 2026Article
- Convergence of plasmid-driven virulence and antibiotic resistance in Escherichia coli.Nature communications · 2025Article
- Lineage-specific variation in frequency and hotspots of recombination in invasive Escherichia coli.BMC genomics · 2025Article
- Nitroxoline resistance is associated with significant fitness loss and diminishesMicrobiology spectrum · 2024Article
- The clinical, genomic, and microbiological profile of invasive multi-drug resistantMicrobial genomics · 2023Article
- Escherichia coli ST131 Associated with Increased Mortality in Bloodstream Infections from Urinary Tract Source.Journal of clinical microbiology · 2023Article
- Genetic basis of I-complex plasmid stability and conjugation.PLoS genetics · 2023Article
- Convergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves.Scientific reports · 2022Article
- Effects of Yellow Light on Airborne Microbial Composition and on the Transcriptome of Typical Marker Strain in Ward.Disease markers · 2022Article
- Flagella, Type I Fimbriae and Curli of UropathogenicMicroorganisms · 2021Article
- Comprehensive analysis of IncC plasmid conjugation identifies a crucial role for the transcriptional regulator AcaB.Nature microbiology · 2020Article
- Article
- QseC Signaling in the Outbreak O104:H4Journal of bacteriology · 2019Article
- Physical Extraction and Fast Protein Liquid Chromatography for Purifying Flagella Filament From UropathogenicFrontiers in cellular and infection microbiology · 2019Article
- Intestinal Colonization Traits of Pandemic Multidrug-Resistant Escherichia coli ST131.The Journal of infectious diseases · 2018Article
- Growth rate control of flagellar assembly in Escherichia coli strain RP437.Scientific reports · 2017Article
- An Overview of Two-Component Signal Transduction Systems Implicated in Extra-Intestinal PathogenicFrontiers in cellular and infection microbiology · 2017Review
- Article
- Invasion of Host Cells and Tissues by Uropathogenic Bacteria.Microbiology spectrum · 2016Review
- Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Escherichia coli sequence type 131 (ST131) is a globally dominant multidrug resistant clone associated with urinary tract and bloodstream infections. Most ST131 strains exhibit resistance to multiple antibiotics and cause infections associated with limited treatment options. The largest sub-clonal ST131 lineage is resistant to fluoroquinolones, contains the type 1 fimbriae fimH30 allele and expresses an H4 flagella antigen. Flagella are motility organelles that contribute to UPEC colonisation of the upper urinary tract. In this study, we examined the specific role of H4 flagella in ST131 motility and interaction with host epithelial and immune cells. We show that the majority of H4-positive ST131 strains are motile and are enriched for flagella expression during static pellicle growth. We also tested the role of H4 flagella in ST131 through the construction of specific mutants, over-expression strains and isogenic mutants that expressed alternative H1 and H7 flagellar subtypes. Overall, our results revealed that H4, H1 and H7 flagella possess conserved phenotypes with regards to motility, epithelial cell adhesion, invasion and uptake by macrophages. In contrast, H4 flagella trigger enhanced induction of the anti-inflammatory cytokine IL-10 compared to H1 and H7 flagella, a property that may contribute to ST131 fitness in the urinary tract.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.