Evidence map›Paper›PMID 26547922›Full record

ArticleEuropean journal of drug metabolism and pharmacokinetics2016

Prediction of Antimalarial Drug Clearance in Children: A Comparison of Three Different Interspecies Scaling Methods.

Iftekhar Mahmood, Anna Cheng, Edward Brauer, Rita Humeniuk

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European journal of drug metabolism and pharmacokinetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Iftekhar MahmoodDivision of Hematology Clinical Review, Office of Blood Review and Research (OBRR), Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 20993-0002, USA. Iftekhar.mahmood@fda.hhs.gov.
Anna ChengSchool of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA, 90089, USA.
Edward BrauerSchool of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA, 90089, USA.
Rita HumeniukOffice of the Commissioner, US Food and Drug Administration, Silver Spring, MD, 20993-0002, USA.
Food and Drug Administration · THSouthern California University for Professional Studies · USUnited States Food and Drug Administration · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveAllometric scaling is extensively used for the prediction of pharmacokinetic parameters from animals to humans and is often used for the selection of first-in-human dose. Allometric scaling can also be used to predict a pharmacokinetic parameter in children from adult data including animal species such as rat and dog. The current study was undertaken to evaluate if the clearances of antimalarial drugs in children with malaria can be predicted allometrically (interspecies scaling) from adult rat, dog, and human adult (healthy as well patients with malaria) clearance values.

methodsThree methods [simple allometry, maximum lifespan potential (MLP), and MLP with an empirical correction factor] using clearance values from adult rat, dog, and adult humans with and without malaria were used for the prediction of antimalarial drug clearance in children with malaria.

resultsThe results of this study indicated that the simple allometry would systematically over-predict antimalarial drug clearance in children with malaria whereas the application of MLP would under-predict the clearances of these drugs in children. Therefore, an empirical correction factor was introduced to MLP which substantially improved the antimalarial drug clearances in children.

conclusionsOverall, the results of the study indicated that interspecies scaling using adult rat, dog, and human clearance values of antimalarial drugs could possibly be used to predict drug clearance in children with malaria of different age groups and may be useful during pediatric drug development of antimalarial drugs.

Indexed as

Models, BiologicalAdolescentAdultAge FactorsAlgorithmsAnimalsAntimalarialsChildChild, PreschoolClinical Studies as TopicDogsDrug Dosage CalculationsHalf-LifeHumansInfantInfant, NewbornAntimalarials

Identifiers

PMID26547922
OpenAlexW2112150476

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.