Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2016
Frailty Change and Major Osteoporotic Fracture in the Elderly: Data from the Global Longitudinal Study of Osteoporosis in Women 3-Year Hamilton Cohort.
Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- A Systematic Review of Frailty Trajectories: Their Shape and Influencing Factors.The Gerontologist · 2021Pooled it
- The Relationship Between Fragility Fractures and Pain Experience: A Systematic Review.Frontiers in medicine · 2021Pooled it
- Increased all-cause mortality following distal radius fractures in Danish adults: a register-based matched cohort study.Acta orthopaedica · 2026Article
- An explainable machine learning model predicts 30-day readmission after vertebral augmentation.iScience · 2026Article
- Frailty as a predictor of vertebral fractures in osteoporosis: A clinical perspective.Joint diseases and related surgery · 2025Article
- The mediating role of caffeine and biological age in the association between dietary index for gut microbiota and osteoporosis.Frontiers in nutrition · 2025Article
- Postfracture survival in a population-based study of adults aged ≥66 yr: a call to action at hospital discharge.JBMR plus · 2024Article
- Complex interplay of oral health, muscle and bone metabolism, and frailty in older individuals.Clinical oral investigations · 2024Article
- Effects of Frailty Syndrome on Osteoporosis, Focusing on the Mediating Effect of Muscle Strength and Balance in Community-Dwelling Older Adults (≥60 years) in Iran: Results From the Amirkola Health and Aging Project Cohort Study.Geriatric orthopaedic surgery & rehabilitation · 2024Article
- Medical optimization of osteoporosis for adult spinal deformity surgery: a state-of-the-art evidence-based review of current pharmacotherapy.Spine deformity · 2023Review
- Study on Risk Factors of Primary Non-traumatic OVCF in Chinese Elderly and a Novel Prediction Model.Orthopaedic surgery · 2022Article
- Osteoporosis, fracture and survival: Application of machine learning in breast cancer prediction models.Frontiers in oncology · 2022Article
- Risk Factors of Frailty in Patients with Distal Radius Fractures.Geriatric orthopaedic surgery & rehabilitation · 2022Article
- In community-dwelling women frailty is associated with imminent risk of osteoporotic fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Closing the Osteoporosis Care Gap.Current osteoporosis reports · 2021Review
- The association between a fracture risk tool and frailty: Geelong Osteoporosis Study.BMC geriatrics · 2020Article
- Frailty in Rheumatic Diseases.Frontiers in immunology · 2020Review
- Associations of LRP5 Gene With Bone Mineral Density, Bone Turnover Markers, and Fractures in the Elderly With Osteoporosis.Frontiers in endocrinology · 2020Article
- Challenges and opportunities to improve fracture liaison service attendance: fracture registration and patient characteristics and motivations.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Frailty, transition in frailty status and all-cause mortality in older adults of a Taichung community-based population.BMC geriatrics · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Investigating the cumulative rate of deficits and the change of a frailty index (FI) chronologically is helpful in clinical and research settings in the elderly. However, limited evidence for the change of frailty before and after some nonfatal adverse health event such as a major osteoporotic fracture (MOF) is available. Data from the Global Longitudinal Study of Osteoporosis in Women 3-Year Hamilton cohort were used in this study. The changes of FI before and after onset of MOF were compared between the women with and without incident MOF. We also evaluated the relationship between risk of MOF, falls, and death and the change of FI and the absolute FI measures. There were 3985 women included in this study (mean age 69.4 years). The change of FI was significantly larger in the women with MOF than those without MOF at year 1 (0.085 versus 0.067, p = 0.036) and year 2 (0.080 versus 0.052, p = 0.042) post-baseline. The FI change was not significantly related with risk of MOF independently of age. However, the absolute FI measures were significantly associated with increased risk of MOF, falls, and death independently of age. In summary, the increase of the FI is significantly larger in the elderly women experiencing a MOF than their peer controls, indicating their worsening frailty and greater deficit accumulation after a MOF. Measures of the FI change may aid in the understanding of cumulative aging nature in the elderly and serve as an instrument for intervention planning and assessment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.