Evidence map›Paper›PMID 26547756›Full record

ArticleDigestive diseases and sciences2016

The Density of Interstitial Cells of Cajal Is Diminished in Choledochal Cysts.

Osman Z Karakuş, Oktay Ulusoy, Güray Aktürk, Oğuz Ateş, Esra G Olgun, Mustafa Dalgıç, Gülce Hakgüder, Erdener Özer, Mustafa Olguner, Feza M Akgür

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Article in Digestive diseases and sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Telocytes and interstitial cells of Cajal in the biliary system.Journal of cellular and molecular medicine · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Osman Z KarakuşDepartment of Pediatric Surgery, Dokuz Eylül University, Medical School, Izmir, Turkey. osman.karakus@deu.edu.tr.ORCID http://orcid.org/0000-0002-5083-3647
Oktay UlusoyDepartment of Pediatric Surgery, Dokuz Eylül University, Medical School, Izmir, Turkey.
Güray AktürkDepartment of Pathology, Dokuz Eylül University, Medical School, Izmir, Turkey.
Oğuz AteşDepartment of Pediatric Surgery, Dokuz Eylül University, Medical School, Izmir, Turkey.
Esra G OlgunDepartment of Morgue, Regional Center, Forensic Medicine Institutions, Izmir, Turkey.
Mustafa DalgıçDepartment of Morgue, Regional Center, Forensic Medicine Institutions, Izmir, Turkey.
Gülce HakgüderDepartment of Pediatric Surgery, Dokuz Eylül University, Medical School, Izmir, Turkey.
Erdener ÖzerDepartment of Pathology, Dokuz Eylül University, Medical School, Izmir, Turkey.
Mustafa OlgunerDepartment of Pediatric Surgery, Dokuz Eylül University, Medical School, Izmir, Turkey.
Feza M AkgürDepartment of Pediatric Surgery, Dokuz Eylül University, Medical School, Izmir, Turkey.
Dokuz Eylül University · TRIzmir University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsInterstitial cells of Cajal (ICC) have been shown to be present in the extrahepatic biliary tract of animals and humans. However, ICC distribution in choledochal cysts (CC) has not been investigated. A study was conducted to investigate the distribution of ICC in the extrahepatic biliary tract, including CC, in pediatric human specimens.

methodThe specimens were divided into two main groups as gallbladders and common bile ducts. Gallbladders were obtained from the cholelithiasis, CC operations and autopsies. Common bile ducts were obtained from autopsies. Tissues were stained using c-kit immunohistochemical staining. ICC were assessed semi-quantitatively by applying morphological criteria and were counted as the number of cells/0.24 mm(2) in each area under light microscopy.

resultsA total of 35 gallbladders and 14 CC were obtained from operations. Ten gallbladders plus common bile ducts were obtained from autopsies. The mean numbers of ICC in the gallbladders of cholelithiasis and the gallbladders of CC were 12.2 ± 4.9 and 5.3 ± 1.2, respectively (p = 0.003). The mean numbers of ICC in the common bile ducts and CC were 9.8 ± 2.9 and 3.4 ± 1.4, respectively (p = 0.001).

conclusionThe scarcity of ICC in the extrahepatic biliary tract may be responsible for the etiopathogenesis of the CC.

Indexed as

AdolescentCase-Control StudiesCell CountChildChild, PreschoolCholecystectomyCholedochal CystCholelithiasisCommon Bile DuctFemaleGallbladderHumansImmunohistochemistryInfantInterstitial Cells of CajalMaleProto-Oncogene Proteins c-kitCholedochal cystsCommon bile ductExtrahepatic biliary systemGallbladderInterstitial cells of Cajal

Identifiers

PMID26547756
OpenAlexW2128740280

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.