ArticleEuropean journal of nuclear medicine and molecular imaging2016
The diagnostic value of [(18)F]FDG PET for the detection of chronic osteomyelitis and implant-associated infection.
Article in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- EANM/SNMMI guideline/procedure standard for [European journal of nuclear medicine and molecular imaging · 2025Guideline
- Comparative diagnostic accuracy of respective nuclear imaging for suspected fracture-related infection: a systematic review and Bayesian network meta-analysis.Archives of orthopaedic and trauma surgery · 2021Pooled it
- Accuracy of diagnostic imaging modalities for peripheral post-traumatic osteomyelitis - a systematic review of the recent literature.European journal of nuclear medicine and molecular imaging · 2017Pooled it
- [American journal of nuclear medicine and molecular imaging · 2026Review
- Managing Nonunions and Fracture-Related Infections-A Quarter Century of Knowledge, and Still Curious: A Narrative Review.Journal of clinical medicine · 2025Review
- Predictive Value ofDiagnostics (Basel, Switzerland) · 2025Article
- Bones on fire: illuminating osteomyelitis through the radiant lens ofFrontiers in immunology · 2024Review
- Article
- Total-Body Multiparametric PET Quantification ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Emerging Technologies in Diagnosing Periprosthetic Joint Infections.Indian journal of orthopaedics · 2023Review
- Implant Imaging: Perspectives of Nuclear Imaging in Implant, Biomaterial, and Stem Cell Research.Bioengineering (Basel, Switzerland) · 2023Review
- Total-Body Multiparametric PET Quantification ofmedRxiv : the preprint server for health sciences · 2023Article
- Inguinal draining-lymph node inFrontiers in immunology · 2023Article
- [Update on non-unions 2022 : Imaging diagnostics, classification and treatment algorithms].Unfallchirurgie (Heidelberg, Germany) · 2022Review
- Diagnostic value of hybrid FDG-PET/MR imaging of chronic osteomyelitis.European journal of hybrid imaging · 2022Article
- Role of Animal Models to Advance Research of Bacterial Osteomyelitis.Frontiers in veterinary science · 2022Review
- Bone and Joint Infections: The Role of Imaging in Tailoring Diagnosis to Improve Patients' Care.Journal of personalized medicine · 2021Review
- Progress in diagnosis and treatment of post-traumatic osteomyelitis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Article
- Current opinions on the mechanism, classification, imaging diagnosis and treatment of post-traumatic osteomyelitis.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2021Review
- Impact of unknown incidental findings in PET/CT examinations of patients with proven or suspected vascular graft or endograft infections.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe diagnosis of osteomyelitis and implant-associated infections in patients with nonspecific laboratory or radiological findings is often unsatisfactory. We retrospectively evaluated the contributions of [(18)F]FDG PET and [(18)F]FDG PET/CT to the diagnosis of osteomyelitis and implant-associated infections, enabling timely and appropriate decision-making for further therapy options.
methods[(18)F]FDG PET or PET/CT was performed in 215 patients with suspected osteomyelitis or implant-associated infections between 2000 and 2013. We assessed the diagnostic accuracy of both modalities together and separately with reference to intraoperative microbial findings, with a mean clinical follow-up of 69 ± 49 months.
resultsInfections were diagnosed clinically in 101 of the 215 patients. PET and PET/CT scans revealed 87 true-positive, 76 true-negative, 38 false-positive, and 14 false-negative results, indicating a sensitivity of 86 %, a specificity of 67 %, a positive predictive value (PPV) of 70 %, a negative predictive value (NPV) of 84 % and an accuracy of 76 %. The sensitivity of PET/CT was 88 %, but specificity, PPV, NPV and accuracy (76 %, 76 %, 89 % and 82 %, respectively) were higher than those of stand-alone PET.
conclusion[(18)F]FDG PET is able to identify with high sensitivity the presence of osteomyelitis in orthopaedic surgery patients with nonspecific clinical symptoms of infection.
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