Evidence map›Paper›PMID 26547700›Full record

Trial reportBrazilian journal of otorhinolaryngology

Antioxidant therapy in the elderly with tinnitus.

José Fernando Polanski, Alexandra Dezani Soares, Oswaldo Laércio de Mendonça Cruz

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05646693 phase2unknown statusnot on this map

Effect of Combined Antioxidant Therapy on Oxidative Stress Markers and Inflammatory in Patients With Chronic Subjective Endotic Tinnitus

TypeinterventionalSponsorUniversity of GuadalajaraRan2022 to 2024Enrolled58ConditionsTinnitus, Subjective, Tinnitus, Bilateral, Antioxidant Therapy, Psychiatric DrugsArmsDrusen Mega®, Sertraline, Placebo
NCT06718452 nanot yet recruitingnot on this map

Treatment of Tinnitus Targeting Neuroinflammation. umPEALUT as Possible Option

TypeinterventionalSponsorUniversity of Campania Luigi VanvitelliRan2026 to 2026Enrolled100ConditionsTinnitus, NeuroinflammationArmsPEA-LUT 2 sachet day, Placebo, umPEALUT + Rutin + 5 hTp
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Ginkgo biloba for tinnitus.The Cochrane database of systematic reviews · 2022
    Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. A Comprehensive Study of Oxidative Stress in Tinnitus Patients.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2018
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

José Fernando PolanskiFederal University of São Paulo (UNIFESP), São Paulo, SP, Brazil; Hospital de Clínicas, Federal University of Paraná (UFPR), Curitiba, PR, Brazil. Electronic address: jfpolanski@gmail.com.
Alexandra Dezani SoaresFederal University of São Paulo (UNIFESP), São Paulo, SP, Brazil.
Oswaldo Laércio de Mendonça CruzFederal University of São Paulo (UNIFESP), São Paulo, SP, Brazil; Department of Otorhinolaryngology and Head and Neck Surgery, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Universidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSeveral approaches have been tried for the treatment of tinnitus, from cognitive-behavioral therapies and sound enrichment to medication. In this context, antioxidants, widely used in numerous areas of medicine, appear to represent a promising approach for the control of this symptom, which often is poorly controlled.

objectiveTo evaluate the effects of antioxidant therapy for tinnitus in a group of elderly patients.

methodsProspective, randomized, double-blinded, placebo-controlled clinical trial. The sample consisted of 58 subjects aged 60 years or older, with a complaint of tinnitus associated with sensorineural hearing loss. These individuals completed the Tinnitus Handicap Inventory (THI) questionnaire before and after six months of therapy. The treatment regimens were: Ginkgo biloba dry extract (120mg/day), α-lipoic acid (60mg/day)+vitamin C (600mg/day), papaverine hydrochloride (100mg/day)+vitamin E (400mg/day), and placebo.

resultsThere was no statistically significant difference between THI by degree (p=0.441) and by score (p=0.848) before and after treatment.

conclusionThere was no benefit from the use of antioxidant agents for tinnitus in this sample.

Indexed as

AgedAged, 80 and overAntioxidantsAscorbic AcidDouble-Blind MethodFemaleGinkgo bilobaHearing Loss, SensorineuralHumansMaleMiddle AgedPapaverinePhytotherapyPlant ExtractsProspective StudiesSeverity of Illness IndexAntioxidantsAscorbic AcidPapaverinePlant ExtractsThioctic AcidVitamin EAgedAntioxidantesAntioxidantsIdosoTinnitusZumbido

Identifiers

PMID26547700
PMCPMC9444615
OpenAlexW2188000916

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.