Evidence map›Paper›PMID 26547489›Full record

ArticleIndoor air2016

Domestic exposure to endotoxin and respiratory morbidity in former smokers with COPD.

S Bose, F Rivera-Mariani, R Chen, D Williams, A Belli, C Aloe, M C McCormack, P N Breysse, N N Hansel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indoor air, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

S BoseDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA. sonasona99@gmail.com.
F Rivera-MarianiDepartment of Biology, Miami Dade College Wolfson Campus, Miami, FL, USA.
R ChenBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
D WilliamsBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
A BelliDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
C AloeDivision of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
M C McCormackDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
P N BreysseBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
N N HanselDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USMiami Dade College · USUniversity of Baltimore · US

Funding

PILOT STUDY--ACID FOG, AN EXPERIMENTAL MODELP30ES003819 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI GROOPMAN, JOHN D · 1985 to 2012
$22.6M
Oxidative Stress & Inflammation in a Human PM Nasal ChallengeP50ES015903 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI BREYSSE, PATRICK N · 2007 to 2011
$12.1M
The role of obesity in biological responses to particulate matter in miceP50ES018176 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2015 to 2019
$4.8M
Project 3: Dissecting the Diet Asthma Relationship in Mice Models of AsthmaP01ES018176 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI BISWAL, SHYAM · 2009 to 2013
$4.2M
The Impact of Indoor Particulate Matter Exposure on Non-Allergic AsthmaK23ES016819 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI MCCORMACK, MEREDITH C · 2008 to 2012
$924k
Domestic endotoxin exposure and chronic obstructive pulmonary diseaseR21ES015781 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2008 to 2009
$451k
NIEHS NIH HHS K23 ES016819NIEHS NIH HHS P01 ES018176NIEHS NIH HHS P30 ES003819NIEHS NIH HHS P50 ES015903NIEHS NIH HHS P50 ES018176NIEHS NIH HHS R21 ES015781
6 · The paper itself

Abstract

Indoor air pollution has been linked to adverse chronic obstructive pulmonary disease (COPD) health, but specific causative agents have not yet been identified. We evaluated the role of indoor endotoxin exposure upon respiratory health in former smokers with COPD. Eighty-four adults with moderate to severe COPD were followed longitudinally and indoor air and dust samples collected at baseline, 3 and 6 months. Respiratory outcomes were repeatedly assessed at each time point. The associations between endotoxin exposure in air and settled dust and health outcomes were explored using generalizing estimating equations in multivariate models accounting for confounders. Dust endotoxin concentrations in the main living area were highest in spring and lowest in fall, while airborne endotoxins remained steady across seasons. Airborne and dust endotoxin concentrations were weakly correlated with one another (rs  = +0.24, P = 0.005). Endotoxin concentrations were not significantly associated with respiratory symptoms, rescue medication use, quality of life, or severe exacerbations. In vitro whole-blood assays of the pro-inflammatory capacity of PM10 filters with and without endotoxin depletion demonstrated that the endotoxin component of indoor air pollution was not the primary trigger for interleukin-1β release. Our findings support that endotoxin is not the major driver in the adverse effects of indoor PM upon COPD morbidity.

Indexed as

AgedAir Pollution, IndoorDustEndotoxinsEnvironmental ExposureFemaleHousingHumansLongitudinal StudiesMaleMiddle AgedPulmonary Disease, Chronic ObstructiveSeasonsSmokingTime FactorsDustEndotoxinsChronic obstructive pulmonary diseaseEndotoxinIndoor airInterleukin-1βParticulate matterPollution

Identifiers

PMID26547489
PMCPMC5324735
OpenAlexW2159354722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.