ArticleJournal of assisted reproduction and genetics2016
Independent factors influencing large-for-gestation birth weight in singletons born after in vitro fertilization.
Article in Journal of assisted reproduction and genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses.BMC pregnancy and childbirth · 2021Pooled it
- Comparison of Fetal Cardiac Function in Structurally Normal Fetuses Conceived Via IVF and Spontaneous Pregnancy: a Prospective Case-Control Study.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- A large-scale prediction model to predict large for gestational age infants conceived by IVF/ICSI.Frontiers in endocrinology · 2026Article
- The impact of reference growth standards on small- and large-for-gestational age outcomes among pregnancies conceived by fresh and frozen embryo transfers.F&S reports · 2024Article
- Associations between Urinary Concentrations of Disinfection Byproducts andEnvironmental health perspectives · 2023Article
- In vitro fertilization as an independent risk factor for perinatal complications: Single-center 10 years cohort study.JBRA assisted reproduction · 2023Article
- Association between infertility treatment and intrauterine growth: a multilevel analysis in a retrospective cohort study.BMJ open · 2020Article
- Effect of embryo and blastocyst transfer on the birthweight of live-born singletons from FET cycles.Journal of assisted reproduction and genetics · 2018Article
- Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study.Reproductive biology and endocrinology : RB&E · 2018Article
- Effect of frozen/thawed embryo transfer on birthweight, macrosomia, and low birthweight rates in US singleton infants.American journal of obstetrics and gynecology · 2018Article
- Pregnancy, birth, and infant outcomes by maternal fertility status: the Massachusetts Outcomes Study of Assisted Reproductive Technology.American journal of obstetrics and gynecology · 2017Article
- Increased risk of large-for-gestational age birthweight in singleton siblings conceived with in vitro fertilization in frozen versus fresh cycles.Journal of assisted reproduction and genetics · 2017Article
- Fresh and Frozen-Thawed Embryo Transfer Compared to Natural Conception: Differences in Perinatal Outcome.Gynecologic and obstetric investigation · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHigher risk for birth of singletons being large for gestational age (LGA) has been revealed after in vitro fertilization (IVF) frozen-thawed embryo-transfer (FET). This phenomenon is now being investigated, since there is a speculation that these neonates could suffer from underlying epigenetic disturbances. The aim of the study was to expose independent LGA risk factors and to identify those connected to the IVF techniques.
methodsAltogether, 4508 singleton pregnancies and births were included in the cohort case-matched study. Two hundred eleven singleton pregnancies and births after FET and 916 after fresh embryo transfer (ET) were included into two study groups. The IVF procedures were performed at the University Medical Centre Ljubljana between 2004 and 2011. For each IVF pregnancy, three matched consecutive controls after natural conception were included. Using logistic regression models, we observed LGA connection to maternal parameters (smoking, hypertension, parity, BMI, gestational diabetes, IVF conception, FET, double ET, and ICSI procedure).
resultsSingletons born after FET had a significantly higher risk for being LGA (p = 0.032; OR 1.697; 95 % CI 1.047-2.752). BMI 25-30 was a significant independent risk factor for LGA in the IVF groups (FET p = 0.041, OR 2.460, 95 % CI 1.030-5.857 and fresh ET p = 0.003; OR 2.188, 95 % CI 1.297-3.691). ICSI and double ET had no significant effect on LGA occurrence.
conclusionsBesides maternal BMI, FET is a significant independent LGA risk factor in IVF patients. Other observed factors (smoking, hypertension, multiparity, GDM, ICSI procedure, or number of embryos transferred) do not influence LGA risk significantly.
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