Evidence map›Paper›PMID 26547142›Full record

ArticleActa ophthalmologica2016

Hearing in older adults with exfoliation syndrome/exfoliation glaucoma or primary open-angle glaucoma.

Geir Tryggvason, Fridbert Jonasson, Mary Frances Cotch, Chuan-Ming Li, Howard J Hoffman, Christa L Themann, Gudny Eiriksdottir, Jóhanna Eyrún Sverrisdottir, Tamara B Harris, Lenore J Launer and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta ophthalmologica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Geir TryggvasonDepartment of Otolaryngology-Head and Neck Surgery, Oslo University Hospital, Oslo, Norway.
Fridbert JonassonDepartment of Ophthalmology, Landspitali University Hospital, Reykjavik, Iceland.
Mary Frances CotchDivision of Epidemiology and Clinical Applications, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD, USA.
Chuan-Ming LiEpidemiology and Statistics Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH), Bethesda, MD, USA.
Howard J HoffmanEpidemiology and Statistics Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH), Bethesda, MD, USA.
Christa L ThemannHearing Loss Prevention Team, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Cincinnati, OH, USA.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Jóhanna Eyrún SverrisdottirIcelandic Heart Association, Kopavogur, Iceland.
Tamara B HarrisLaboratory of Population Sciences, National Institute on Aging (NIA), National Institutes of Health (NIH), Bethesda, MD, USA.
Lenore J LaunerLaboratory of Population Sciences, National Institute on Aging (NIA), National Institutes of Health (NIH), Bethesda, MD, USA.
Vilmundur GudnasonFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Hannes PetersenFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
National Institutes of Health · USIcelandic Heart Association · ISNational Institute for Occupational Safety and Health · USNational Institute on Aging · USOslo University Hospital · NOReykjavík University · ISUniversity of Iceland · IS

Funding

CLINICAL PROJECT: Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective studyZIAAG007380 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2009 to 2025
$6.1M
Age, Gene/environment Susceptibility Study In Iceland - Ocular ComponentZIAEY000401 · NEI · NATIONAL EYE INSTITUTE · PI COTCH, MARY FRANCES · 2009 to 2020
$3.3M
Gene/environment Susceptibility Iceland-Ocular ComponentZ01EY000401 · NEI · NATIONAL EYE INSTITUTE · PI COTCH, MARY FRANCES · 2002 to 2008
$258k
AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-26012100N01AG012100 · NIA · ICELANDIC HEART ASSOCIATION · 2002 to 2004
–
Intramural NIH HHS Z01 EY000401Intramural NIH HHS Z99 EY999999Intramural NIH HHS ZIA EY000401NIA NIH HHS N01-AG-1-2100PHS HHS ZIAEY000401
6 · The paper itself

Abstract

purposeTo determine whether adults, aged 66-96 years, with exfoliation syndrome (XFS)/exfoliation glaucoma (XFG), or primary open-angle glaucoma (POAG) have poorer hearing than controls of similar age.

methodsCase (XFS/XFG and POAG) and control status was diagnosed in the Reykjavik Glaucoma Studies (RGS) using slit-lamp examination, visual field testing and optic disc photographs; the RGS data were merged with the Age, Gene/Environment Susceptibility-Reykjavik Study that collected hearing data using air-conduction, pure-tone thresholds obtained at 0.5, 1, 2, 3, 4, 6 and 8 kHz categorized by better ear and worse ear, based on pure-tone averages (PTAs) calculated separately for low and middle frequencies (PTA512 - mean of thresholds at 0.5, 1 and 2 kHz) and high frequencies (PTA3468 - mean of thresholds at 3, 4, 6 and 8 kHz). Multivariable linear regression was used to test for differences in PTAs between cases and controls.

resultsThe mean age for 158 XFS/XFG cases (30.4% male) was 77.4 years, 95 POAG cases (35.8% male) was 77.9 years, and 123 controls (46.3% male) was 76.8 years. Using multivariable linear regression analysis, there were no consistent, statistically significant differences in PTAs between the two case groups and controls in either the low- or high-frequency range, even when stratified by age group.

conclusionAmong the older individuals examined in this study hearing loss is highly prevalent and strongly associated with male gender and increasing age. As we did not find consistent statistically significant difference in hearing between cases and controls the diagnosis of XFS/XFG or POAG does not as such routinely call for audiological evaluation.

Indexed as

AgedAged, 80 and overAudiometry, Pure-ToneExfoliation SyndromeFemaleGlaucoma, Open-AngleHearing DisordersHumansIntraocular PressureMaleVisual FieldsVisual Field Testsadjustment for age and sexexfoliation glaucomahearingprimary open-angle glaucoma

Identifiers

PMID26547142
PMCPMC4764451
OpenAlexW2141428104

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.