ArticleInternational journal of cancer2016
High hemoglobin A1c levels within the non-diabetic range are associated with the risk of all cancers.
Article in International journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Association of Measures of Glucose Metabolism with Colorectal Cancer Risk in Older Chinese: A 13-Year Follow-up of the Guangzhou Biobank Cohort Study-Cardiovascular Disease Substudy and Meta-Analysis.Diabetes & metabolism journal · 2024Pooled it
- Haemoglobin A1c and serum glucose levels and risk of gastric cancer: a systematic review and meta-analysis.British journal of cancer · 2022Pooled it
- Contribution of Diabetes to the Incidence and Prevalence of Comorbid Conditions (Cancer, Periodontal Disease, Fracture, Impaired Cognitive Function, and Depression): A Systematic Review of Epidemiological Studies in Japanese Populations.Journal of epidemiology · 2019Pooled it
- Pooled it
- Interplay of glycated hemoglobin and traditional risk factors for the risk of atherosclerotic cardiovascular disease and all-cause mortality in people without diabetes.Cardiovascular diabetology · 2025Observational
- Longitudinal changes in metabolism-related metrics and breast cancer risk: a general population study.Breast cancer research : BCR · 2025Article
- Article
- A low-glucose eating pattern is associated with improvements in glycemic variability among women at risk for postmenopausal breast cancer: an exploratory analysis.Frontiers in nutrition · 2024Article
- Association of Metabolic Syndrome With Risk of Lung Cancer: A Population-Based Prospective Cohort Study.Chest · 2024Article
- Diet quality and lung cancer incidence in a low-income population in the United States.British journal of cancer · 2023Article
- Associations between dairy intake and mortality due to all-cause and cardiovascular disease: the Japan Public Health Center-based prospective study.European journal of nutrition · 2023Article
- Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation.Scientific reports · 2023Article
- Association of Glycosylated Hemoglobin Level and Cancer-Related Mortality in Patients without Diabetes.Journal of clinical medicine · 2022Article
- Prospective associations of hemoglobin ACancer research communications · 2022Article
- Associations Between Device-Measured Physical Activity and Glycemic Control and Variability Indices Under Free-Living Conditions.Diabetes technology & therapeutics · 2022Article
- Interrogating Patterns of Cancer Disparities by Expanding the Social Determinants of Health Framework to Include Biological Pathways of Social Experiences.International journal of environmental research and public health · 2022Review
- A retrospective cohort study on the association between poor sleep quality in junior high school students and high hemoglobin A1c level in early adults with higher body mass index values.BMC endocrine disorders · 2022Article
- Comment on 'hemoglobin A1c and serum glucose levels and risk of gastric cancer: A systematic review and meta-analysis'.Frontiers in endocrinology · 2022Article
- Glycemic Control as an Early Prognostic Marker in Advanced Pancreatic Cancer.Frontiers in oncology · 2021Article
- Risk of 16 cancers across the full glycemic spectrum: a population-based cohort study using the UK Biobank.BMJ open diabetes research & care · 2020Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have reported associations between diabetes and cancer risk. However, specific association of hemoglobin A1c (HbA1c) levels with cancer risk remains inconclusive. We followed 29,629 individuals (11,336 men; 18,293 women) aged 46-80 years who participated in the Japan Public Health Center-based prospective study who had HbA1c measurements available and were cancer-free at baseline. Cancer incidence was assessed by systemic surveys. We estimated hazard ratios (HRs) for cancer risk with adjustment for age sex, geographic area, body mass index, smoking status, physical activity, alcohol, coffee, vegetable and total energy consumption, and history of cardiovascular disease. After a median follow-up of 8.5 years, 1,955 individuals had developed cancer. Higher HbA1c levels within both the non-diabetic and diabetic ranges in individuals without known diabetes were associated with overall cancer risk. Compared with individuals without known diabetes and HbA1c levels of 5.0-5.4%, the HRs for all cancers were 1.27 (95% confidence interval, 1.07-1.52); 1.01 (0.90-1.14); 1.28 (1.09-1.49); and 1.43 (1.14-1.80) for individuals without known diabetes and HbA1c levels <5.0%, 5.5-5.9%, 6.0-6.4%, and ≥6.5%, respectively, and 1.23 (1.02-1.47) for individuals with known diabetes. The lowest HbA1c group had the highest risk of liver cancer, and HbA1c levels were linearly associated with the risk of all cancers after excluding liver cancer (P for linear trend, 0.004). In conclusion, our findings corroborate the notion that glycemic control in individuals with high HbA1c levels may be important not only to prevent diabetes but also to prevent cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.