ArticleExperimental neurology2016
Dysfunction in amygdala-prefrontal plasticity and extinction-resistant avoidance: A model for anxiety disorder vulnerability.
Article in Experimental neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Diverging Effects of Violence Exposure and Psychiatric Symptoms on Amygdala-Prefrontal Maturation During Childhood and Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Differential Effects of Neonatal Ventral Hippocampus Lesion on Behavior and Corticolimbic Plasticity in Wistar-Kyoto and Spontaneously Hypertensive Rats.Neurochemical research · 2024Article
- Validation of the Chinese version of the adverse life experiences scale.Frontiers in pediatrics · 2024Article
- Bdnf-Nrf-2 crosstalk and emotional behavior are disrupted in a sex-dependent fashion in adolescent mice exposed to maternal stress or maternal obesity.Translational psychiatry · 2023Article
- Anxiety and depression: A top-down, bottom-up model of circuit function.Annals of the New York Academy of Sciences · 2023Review
- Weaker situations: Uncertainty reveals individual differences in learning: Implications for PTSD.Cognitive, affective & behavioral neuroscience · 2023Review
- Daytime Light Deficiency Leads to Sex- and Brain Region-Specific Neuroinflammatory Responses in a Diurnal Rodent.Cellular and molecular neurobiology · 2023Article
- Effects of bright light therapy on neuroinflammatory and neuroplasticity markers in a diurnal rodent model of Seasonal Affective Disorder.Annals of medicine · 2023Article
- Coordinated Prefrontal State Transition Leads Extinction of Reward-Seeking Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Greater age-related changes in white matter morphometry following early life stress: Associations with internalizing problems in adolescence.Developmental cognitive neuroscience · 2021Article
- Electroacupuncture Ameliorates Depression-Like Behaviour in Rats by Enhancing Synaptic Plasticity via the GluN2B/CaMKII/CREB Signalling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- A reinforcement-learning model of active avoidance behavior: Differences between Sprague Dawley and Wistar-Kyoto rats.Behavioural brain research · 2020Article
- Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression.Molecular brain · 2020Article
- Article
- Sex Differences in the Development of the Rodent Corticolimbic System.Frontiers in neuroscience · 2020Review
- Inhibited Personality Temperaments Translated Through Enhanced Avoidance and Associative Learning Increase Vulnerability for PTSD.Frontiers in psychology · 2019Review
- Prefrontal circuits signaling active avoidance retrieval and extinction.Psychopharmacology · 2019Article
- N-Methyl D-aspartate receptor subunit signaling in fear extinction.Psychopharmacology · 2019Review
- Alteration of BDNF in the medial prefrontal cortex and the ventral hippocampus impairs extinction of avoidance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Reduced Microglial Activity and Enhanced Glutamate Transmission in the Basolateral Amygdala in Early CNS Autoimmunity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Individuals exhibiting an anxiety disorder are believed to possess an innate vulnerability that makes them susceptible to the disorder. Anxiety disorders are also associated with abnormalities in the interconnected brain regions of the amygdala and prefrontal cortex (PFC). However, the link between anxiety vulnerability and amygdala-PFC dysfunction is currently unclear. Accordingly, the present study sought to determine if innate dysfunction within the amygdala to PFC projection underlies the susceptibility to develop anxiety-like behavior, using an anxiety vulnerable rodent model. The inbred Wistar Kyoto (WKY) rat was used to model vulnerability, as this strain naturally expresses extinction-resistant avoidance; a behavior that models the symptom of avoidance present in anxiety disorders. Synaptic plasticity was assessed within the projection from the basolateral nucleus of the amygdala (BLA) to the prelimbic cortical subdivision of the PFC in WKY and Sprague Dawley (SD) rats. While WKY rats exhibited normal paired-pulse plasticity, they did not maintain long-term potentiation (LTP) as SD rats. Thus, impaired plasticity within the BLA-PL cortex projection may contribute to extinction resistant avoidance of WKY, as lesions of the PL cortex in SD rats impaired extinction of avoidance similar to WKY rats. Treatment with d-cycloserine to reverse the impaired LTP in WKY rats was unsuccessful. The lack of LTP in WKY rats was associated with a significant reduction of NMDA receptors containing NR2A subunits in the PL cortex. Thus, dysfunction in amygdala-PFC plasticity is innate in anxiety vulnerable rats and may promote extinction-resistant avoidance by disrupting communication between the amygdala and prefrontal cortex.
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