Evidence map›Paper›PMID 26546783›Full record

ReviewPsychoneuroendocrinology2016

The role of cytokines in the pathophysiology of suicidal behavior.

Licínia Ganança, Maria A Oquendo, Audrey R Tyrka, Sebastian Cisneros-Trujillo, J John Mann, M Elizabeth Sublette

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Psychoneuroendocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04159207 (A Longitudinal Study of Inflammatory Pathways in Depression), which is not on this map. Cited by 100 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 7 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04159207 completednot on this mapstarted 2019, after this paper: background citation

A Longitudinal Study of Inflammatory Pathways in Depression

TypeobservationalSponsorVan Andel Research InstituteRan2019 to 2023Enrolled130ConditionsMajor Depressive Disorder, Suicide, Attempted
3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 7 syntheses or guidelines pooled it, 221 citations in OpenAlex.

  1. Completed suicide in patients with skin disease: A systematic review and meta-analysis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
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  8. Low 5HTJournal of neurochemistry · 2026
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  9. Short-term PMBMC public health · 2026
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Licínia GanançaMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, 10032 NY, USA; Department of Psychiatry, Columbia University, New York, 10032 NY, USA; Department of Psychiatry, School of Medicine, University of Lisbon, 1649-035 Lisbon, Portugal.
Maria A OquendoMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, 10032 NY, USA; Department of Psychiatry, Columbia University, New York, 10032 NY, USA.
Audrey R TyrkaLaboratory for Clinical and Translational Neuroscience, Butler Hospital and Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, 02912 RI, USA.
Sebastian Cisneros-TrujilloMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, 10032 NY, USA; Department of Psychiatry, Columbia University, New York, 10032 NY, USA.
J John MannMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, 10032 NY, USA; Department of Psychiatry, Columbia University, New York, 10032 NY, USA; Department of Radiology, Columbia University, New York, 10032 NY, USA.
M Elizabeth SubletteMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, 10032 NY, USA; Department of Psychiatry, Columbia University, New York, 10032 NY, USA. Electronic address: es2316@cumc.columbia.edu.
New York Psychoanalytic Society and Institute · USBrown University · USColumbia University Irving Medical Center · USUniversity of Lisbon · PT

Funding

Suicidal Behavior: Aggression Subtypes, Childhood Adversity and Stress ResponseP50MH090964 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2013 to 2022
$23.6M
Early Life Stress: Epigenetic Regulation of Endocrine and Immune PathwaysR01MH101107 · NIMH · BUTLER HOSPITAL (PROVIDENCE, RI) · PI TYRKA, AUDREY · 2014 to 2018
$2.6M
Childhood Maltreatment:Biomarkers of Risk and ResilienceR01MH083704 · NIMH · BUTLER HOSPITAL (PROVIDENCE, RI) · PI TYRKA, AUDREY · 2010 to 2014
$2.6M
NIMH NIH HHS MH P50 MH090964NIMH NIH HHS P50 MH090964NIMH NIH HHS R01 MH083704NIMH NIH HHS R01 MH101107
6 · The paper itself

Abstract

objectiveImmune dysregulation has been implicated in depression and other psychiatric disorders. What is less clear is how immune dysregulation can affect risk of suicidal behavior. We reviewed the scientific literature concerning cytokines related to suicidal ideation, suicidal behavior and suicide, and surveyed clinical and neurobiological factors associated with cytokine levels that may modulate effects of inflammation on suicide risk.

methodsWe searched PubMed, Embase, Scopus and PsycINFO for relevant studies published from 1980 through February, 2015. Papers were included if they were written in English and focused on cytokine measurements in patients with suicidal behaviors.

resultsThe literature search yielded 22 studies concerning cytokines and suicidal ideation, suicide attempts or suicide completion. The most consistent finding was elevated interleukin (IL)-6, found in 8 out of 14 studies, in CSF, blood, and postmortem brain. In one study, IL-6 in CSF was also found to be higher in violent than nonviolent attempters and to correlate with future suicide completion. Low plasma IL-2 was observed in 2 studies of suicide attempters, while divergent results were seen for tumor necrosis factor (TNF)-α, interferon (IFN)-γ, transforming growth factor (TGF)-β, IL-4, and soluble Il-2 receptors.

conclusionsGiven the complexity suggested by the heterogenous cytokine findings, putative mediators and moderators of inflammation on suicidal behavior merit further study. Elevated IL-6 was the most robust cytokine finding, associated with suicidal ideation and both nonfatal suicide attempts and suicides. Future studies should evaluate the predictive value of high IL-6, consider how this may alter brain function to impact suicidal behavior, and explore the potential beneficial effects of reducing IL-6 on suicide risk.

Indexed as

Suicidal IdeationCytokinesDepressionHumansInflammationInflammation MediatorsSelf-Injurious BehaviorSuicideSuicide, AttemptedCytokinesInflammation MediatorsCytokinesDepressionInflammationStressSuicide

Identifiers

PMID26546783
PMCPMC4910882
OpenAlexW1771262887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.