Evidence map›Paper›PMID 26546710›Full record

ArticleAtherosclerosis2015

Background differences in baseline and stimulated MMP levels influence abdominal aortic aneurysm susceptibility.

Matthew A Dale, Melissa K Suh, Shijia Zhao, Trevor Meisinger, Linxia Gu, Vicki J Swier, Devendra K Agrawal, Timothy C Greiner, Jeffrey S Carson, B Timothy Baxter and 1 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

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  15. The Role of a Selective P2YBioMed research international · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Matthew A DaleDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE, USA; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Melissa K SuhDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE, USA.
Shijia ZhaoDepartment of Mechanical & Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE, USA.
Trevor MeisingerDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE, USA.
Linxia GuDepartment of Mechanical & Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE, USA.
Vicki J SwierDepartment of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, USA.
Devendra K AgrawalDepartment of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, USA.
Timothy C GreinerDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Jeffrey S CarsonDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE, USA.
B Timothy BaxterDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE, USA; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Wanfen XiongDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: wxiong@unmc.edu.
University of Nebraska Medical Center · USNebraska Medical Center · USCreighton University · USUniversity of Nebraska–Lincoln · US

Funding

Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA^3CT )R01AG037120 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI BAXTER, BERNARD TIMOTHY, CURCI, JOHN A · 2011 to 2017
$12.2M
MMP REGULATION BY DOXYCYCLINE IN AORTIC ANEURYSMR01HL062400 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAXTER, BERNARD TIMOTHY · 2000 to 2015
$3.9M
NHLBI NIH HHS R01 HL062400NIA NIH HHS R01 AG037120
6 · The paper itself

Abstract

objectiveEvidence has demonstrated profound influence of genetic background on cardiovascular phenotypes. Murine models in Marfan syndrome (MFS) have shown that genetic background-related variations affect thoracic aortic aneurysm formation, rupture, and lifespan of mice. MFS mice with C57Bl/6 genetic background are less susceptible to aneurysm formation compared to the 129/SvEv genetic background. In this study, we hypothesize that susceptibility to abdominal aortic aneurysm (AAA) will be increased in 129/SvEv mice versus C57Bl/6 mice. We tested this hypothesis by assessing differences in aneurysm size, tissue properties, immune response, and MMP expression.

methodsMice of C57Bl/6 or 129/SvEv background underwent AAA induction by periaortic application of CaCl2. Baseline aortic diameters, tissue properties and MMP levels were measured. After aneurysm induction, diameters, MMP expression, and immune response (macrophage infiltration and bone marrow transplantation) were measured.

resultsAneurysms were larger in 129/SvEv mice than C57Bl/6 mice (83.0% ± 13.6 increase compared to 57.8% ± 6.4). The aorta was stiffer in the 129/SvEv mice compared to C57Bl/6 mice (952.5 kPa ± 93.6 versus 621.4 kPa ± 84.2). Baseline MMP-2 and post-aneurysm MMP-2 and -9 levels were higher in 129/SvEv aortas compared to C57Bl/6 aortas. Elastic lamella disruption/fragmentation and macrophage infiltration were increased in 129/SvEv mice. Myelogenous cell reversal by bone marrow transplantation did not affect aneurysm size.

conclusionsThese data demonstrate that 129/SvEv mice are more susceptible to AAA compared to C57Bl/6 mice. Intrinsic properties of the aorta between the two strains of mice, including baseline expression of MMP-2, influence susceptibility to AAA.

Indexed as

AnimalsAorta, AbdominalAortic Aneurysm, AbdominalBone Marrow TransplantationCalcium ChlorideDilatation, PathologicDisease Models, AnimalElastic ModulusGenetic Predisposition to DiseaseMacrophagesMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 9Mice, 129 StrainMice, Inbred C57BLPancreatic ElastaseCalcium ChlorideMatrix Metalloproteinase 2Matrix Metalloproteinase 9Mmp2 protein, mouseMmp9 protein, mousePancreatic ElastaseTropoelastinAneurysmAortaMatrix metalloproteinase

Identifiers

PMID26546710
PMCPMC4683999
OpenAlexW2133276778

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.