Evidence map›Paper›PMID 26546503›Full record

ArticleHaematologica2016

Spinal glial activation and oxidative stress are alleviated by treatment with curcumin or coenzyme Q in sickle mice.

Yessenia Valverde, Barbara Benson, Mihir Gupta, Kalpna Gupta

Open access · goldAbstract readLetter
In one paragraph

Article in Haematologica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 48 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Ferroptosis as an emerging target in sickle cell disease.Current research in toxicology · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Pain in sickle cell disease: current and potential translational therapies.Translational research : the journal of laboratory and clinical medicine · 2021
    Review
  14. Ubisol-QAntioxidants (Basel, Switzerland) · 2021
    Review
  15. Mechanisms of pain in sickle cell disease.British journal of pain · 2021
    Article
  16. Article
  17. Heme Causes Pain in Sickle MiceAntioxidants & redox signaling · 2021
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yessenia ValverdeVascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN.
Barbara BensonVascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN.
Mihir GuptaDepartment of Neurosurgery, University of California San Diego, La Jolla, CA, USA.
Kalpna GuptaVascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN gupta014@umn.edu.
University of Minnesota · USUniversity of California, San Diego · US

Funding

Cannabinoid-based therapy and approaches to quantify pain in sickle cell diseaseU01HL117664 · NHLBI · UNIVERSITY OF MINNESOTA · PI GUPTA, KALPNA · 2013 to 2018
$9.6M
Characteristics and mechanisms of pain in sickle cell diseaseR01HL103733 · NHLBI · UNIVERSITY OF MINNESOTA · PI GUPTA, KALPNA, SIMONE, DONALD · 2010 to 2014
$1.9M
NHLBI NIH HHS R01 HL103733NHLBI NIH HHS U01 HL117664NHLBI NIH HHS UO1 HL117664PHS HHS R01 103773
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Administration, OralAnemia, Sickle CellAnimalsAntioxidantsAstrocytesCurcuminDisease Models, AnimalFemaleGene Expression RegulationGlial Fibrillary Acidic ProteinHumansHyperalgesiaMiceMice, TransgenicMicrogliaNeuronsAntioxidantsCurcuminGlial Fibrillary Acidic Proteinglial fibrillary astrocytic protein, mouseNeuropeptidesneuropeptide S, mouseReactive Oxygen SpeciesUbiquinoneastrocyteCoQ10curcuminglialpainsickle cell anemia

Identifiers

PMID26546503
PMCPMC4938337
OpenAlexW2157405237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.