Evidence map›Paper›PMID 26546479›Full record

ReviewBiochimica et biophysica acta2016

Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology.

Makoto Ishii, Costantino Iadecola

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochimica et biophysica acta, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Pathway enrichment in genome-wide analysis of longitudinal Alzheimer's disease biomarker endophenotypes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  8. Article
  9. Neuro-Adipokine Crosstalk in Alzheimer's Disease.International journal of molecular sciences · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Weight Loss and Alzheimer's Disease in Down Syndrome.Journal of Alzheimer's disease : JAD · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Medical complications of obesity: heightened importance in a COVID era.International journal of emergency medicine · 2022
    Review
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Makoto IshiiFeil Family Brain and Mind Research Institute, Joan and Sanford I. Weill Medical College of Cornell University, USA.
Costantino IadecolaFeil Family Brain and Mind Research Institute, Joan and Sanford I. Weill Medical College of Cornell University, USA. Electronic address: coi2001@med.cornell.edu.
Cornell University · US

Funding

Overexpression of the amyloid precursor protein and cerebrovascular regulationR01NS037853 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Costantino Iadecola · 1998 to 2026
$10.6M
Pathobiology of Hypothalamic and Metabolic Dysfunction in Normal Aging and Alzheimer's DiseaseK08AG051179 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI ISHII, MAKOTO · 2015 to 2019
$864k
NIA NIH HHS K08 AG051179NINDS NIH HHS R01 NS037853
6 · The paper itself

Abstract

Age-related dementia is increasingly recognized as having a mixed pathology, with contributions from both cerebrovascular factors and pathogenic factors associated with Alzheimer's disease (AD). Furthermore, there is accumulating evidence that vascular risk factors in midlife, e.g., obesity, diabetes, and hypertension, increase the risk of developing late-life dementia. Since obesity and changes in body weight/adiposity often drive diabetes and hypertension, understanding the relationship between adiposity and age-related dementia may reveal common underlying mechanisms. Here we offer a brief appraisal of how changes in body weight and adiposity are related to both AD and dementia on vascular basis, and examine the involvement of two key adipocyte-derived hormones: leptin and adiponectin. The evidence suggests that in midlife increased body weight/adiposity and subsequent changes in adipocyte-derived hormones may increase the long-term susceptibility to dementia. On the other hand, later in life, decreases in body weight/adiposity and related hormonal changes are early manifestations of disease that precede the onset of dementia and may promote AD and vascular pathology. Understanding the contribution of adiposity to age-related dementia may help identify the underlying pathological mechanisms common to both vascular dementia and AD, and provide new putative targets for early diagnosis and therapy. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia, edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.

Indexed as

AdipocytesAdiponectinAdipose TissueAdiposityAge FactorsAlzheimer DiseaseAnimalsDementia, VascularHumansLeptinAdiponectinLeptinAdiponectinAdiposityAlzheimer'sDementiaLeptinVascular

Identifiers

PMID26546479
PMCPMC4821723
OpenAlexW2151404981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.