ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2016
Sarcopenia and inflammation are independent predictors of survival in male patients newly diagnosed with small cell lung cancer.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- When the Loss Costs Too Much: A Systematic Review and Meta-Analysis of Sarcopenia in Head and Neck Cancer.Frontiers in oncology · 2019Pooled it
- Geriatric Nutritional Risk Index as a prognostic marker in patients with extensive-stage disease small cell lung cancer: Results from a randomized controlled trial.Thoracic cancer · 2020Trial
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- Sarcopenia-driven gene model as a clinically actionable prognostic signature for head and neck squamous cell carcinoma.Translational cancer research · 2025Article
- Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies.Drugs & aging · 2025Review
- Predictive value of temporal muscle thickness for prognosis in newly diagnosed IDH wild-type glioblastoma patients: evaluated for a Chinese population.European radiology · 2025Article
- Evaluation of the utility of different laboratory test-related sarcopenia indices as predictors of lung cancer mortality.BMC geriatrics · 2025Article
- Psoas Muscle Volume Is a Useful Predictor of Postoperative Outcome in Elderly Patients With Non-Small Cell Lung Cancer.Thoracic cancer · 2025Article
- Body composition alterations in patients with lung cancer.American journal of physiology. Cell physiology · 2025Review
- Lipocalin-2 as a prognostic biomarker and its association with systemic inflammation in small cell lung cancer.Thoracic cancer · 2024Article
- Sarcopenia Identification Using Alternative Vertebral Landmarks in Individuals with Lung Cancer.Muscles (Basel, Switzerland) · 2024Article
- Article
- Prognostic significance of body mass index in small-cell lung cancer: Exploring the relationship with skeletal muscle status.Journal of cachexia, sarcopenia and muscle · 2023Article
- Skeletal muscle index is associated with long term outcomes after lobectomy for non-small cell lung cancer.BMC cancer · 2023Article
- Role ofJapanese journal of radiology · 2023Article
- The possible relation between temporal muscle mass and glioblastoma multiforme prognosis via sarcopenia perspective.Turkish journal of medical sciences · 2023Article
- Prognostic Value of Body Composition and Systemic Inflammatory Markers in Patients with Locally Advanced Cervical Cancer Following Chemoradiotherapy.Journal of inflammation research · 2023Article
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- Article
- The association between thoracic sarcopenia and survival is gender specific in early-stage lung cancer.Journal of thoracic disease · 2022Article
4 more citing papers are in PubMed but not listed here.
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10 authors.
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Abstract
purposeSarcopenia is suggested to be associated with cancer-related inflammation. We assessed the clinical outcome of small cell lung cancer (SCLC) patients according to sarcopenia and the neutrophil-to-lymphocyte ratio (NLR).
methodsA total of 117 male SCLC patients treated with first-line chemo- or chemoradiotherapy were assessed based on a retrospective chart review. The mass of the pectoralis muscle was measured by computed tomography and normalized to height. Patients with the lowest quartile of muscle mass were considered to have sarcopenia. Patients were classified into four groups according to their sarcopenia and NLR statuses: sarcopenia/high NLR, sarcopenia/low NLR, non-sarcopenia/high NLR, and non-sarcopenia/low NLR.
resultsSarcopenic patients had lower progression-free survival (PFS) than did non-sarcopenic patients (median 6.0 vs. 7.5 months, p = 0.009), but the difference in overall survival (OS) was not statistically significant (median 10.5 vs. 13.5 months, p = 0.052). However, the OS of sarcopenic patients with high NLR was significantly lower than that in all other groups (median 3.2 vs. 16.0 vs. 12.5 vs. 13.7 months, respectively, p < 0.001), as was PFS (median 3.2 vs. 7.7 vs. 7.6 vs. 7.1 months, respectively, p < 0.001). On multivariate analysis, sarcopenia with high NLR was an independent prognostic factor for shorter PFS and OS. Early discontinuation of treatment (20.0 vs. 10.3 %) and treatment-related mortality (50.0 vs. 8.4 %) occurred more frequently in these patients than in the other groups (p < 0.001).
conclusionsIn SCLC, sarcopenic male patients with high NLR have a poor prognosis and do not tolerate standard treatment. Intensive supportive care is needed in these patients.
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