ReviewInfection2016
Trichomonas vaginalis: pathogenicity and potential role in human reproductive failure.
Review in Infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- Trichomonas vaginalis infection and risk of cervical neoplasia: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Trichomoniasis and adverse birth outcomes: a systematic review and meta-analysis.BJOG : an international journal of obstetrics and gynaecology · 2021Pooled it
- Global prevalence of Trichomonas vaginalis among female sex workers: a systematic review and meta-analysis.Parasitology research · 2021Pooled it
- Efficacy and Safety of Single Oral Dosing of Secnidazole for Trichomoniasis in Women: Results of a Phase 3, Randomized, Double-Blind, Placebo-Controlled, Delayed-Treatment Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Trial
- Unfolding the Semen Microbiota: Implications for Male Infertility.Biomedicines · 2026Review
- Neutrophil reactive oxygen species response to Trichomonas vaginalis modulated by palmitic acid.Parasites, hosts and diseases · 2026Article
- Global burden of disease and future trends of trichomoniasis in women of reproductive age from 1990 to 2021.Journal of health, population, and nutrition · 2026Article
- Expert Consensus Study on the Redesign of the Sexually Transmitted Infection Surveillance System in Korea.Journal of Korean medical science · 2026Article
- UV-C Light-Based Decontamination of Transvaginal Ultrasound Transducer: An Effective and Fast Way for Patient Safety in Gynecology.Journal of clinical medicine · 2025Article
- Assessment of Knowledge and Attitudes of Undergraduate Students on Trichomoniasis in Ghana.Public health challenges · 2025Article
- Sexually Transmitted Infections: Usefulness of Molecular Methods for Microorganism Detection in Stored Sexual Assault Samples.International journal of molecular sciences · 2025Article
- The association between sexually transmitted infections and pregnancy outcomes in the Northern Territory, Australia: a population-based cohort study.The Lancet regional health. Western Pacific · 2025Article
- Forensic Microbiology: Challenges in Detecting Sexually Transmitted Infections.Diagnostics (Basel, Switzerland) · 2025Review
- 18S rRNA gene metabarcoding for investigation of gastrointestinal parasite diversity in great cormorants.Scientific reports · 2025Article
- Global burden of female infertility attributable to sexually transmitted infections and maternal sepsis: 1990-2021 and projections to 2050.Scientific reports · 2025Article
- Prevalence ofTropical medicine and infectious disease · 2025Review
- Association between Trichomonas vaginalis infection and spontaneous preterm labour in Lagos, Nigeria: an analytical cross-sectional study.BMC research notes · 2025Article
- The prevalence trends of Trichomonas vaginalis infection among women in Jingzhou, central of China, 2019-2023.BMC infectious diseases · 2025Article
- Unveiling shifts in cervical microbiota composition among Colombian women in the presence of Trichomonas vaginalis: a longitudinal study.Parasitology research · 2025Article
- Trichomoniasis in Men: A Neglected Factor in Male Infertility?Acta parasitologica · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTrichomonas vaginalis, which colonizes the genitourinary tract of men and women, is a sexually transmitted parasite causing symptomatic or asymptomatic trichomoniasis. The host-parasite relationship is very complex, and clinical symptoms cannot likely be attributed to a single pathogenic effect. Among the many factors responsible for interactions between T. vaginalis and host tissues, contact-dependent and contact-independent mechanisms are important in pathogenicity, as is the immune response.
methodsThis review focuses on the potential virulence properties of T. vaginalis and its role in female and male infertility.
resultsIt highlights the association between T. vaginalis infection and serious adverse health consequences experienced by women, including infertility, preterm birth and low-birth-weight infants. Long-term clinical observations and results of in vitro experimental studies indicate that in men, trichomoniasis has been also associated with infertility through inflammatory damage to the genitourinary tract or interference with sperm function.
conclusionThese results contribute significantly to improving our knowledge of the role of parasitic virulence factors in the development of infection and its role in human infertility.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.