Evidence map›Paper›PMID 26546184›Full record

ArticleWorld journal of surgery2016

Incidence of Perioperative Complications Following Resection of Adrenocortical Carcinoma and Its Association with Long-Term Survival.

Georgios Antonios Margonis, Neda Amini, Yuhree Kim, Thuy B Tran, Lauren M Postlewait, Shishir K Maithel, Tracy S Wang, Douglas B Evans, Ioannis Hatzaras, Rivfka Shenoy and 18 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Minimally Invasive Resection of Adrenocortical Carcinoma: a Multi-Institutional Study of 201 Patients.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 15 institutions in 1 country.

Georgios Antonios Margonis *Department of Surgery, Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 688, Baltimore, MD 21287, USA.
Neda Amini *Department of Surgery, Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 688, Baltimore, MD 21287, USA.
Yuhree KimDepartment of Surgery, Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 688, Baltimore, MD 21287, USA.
Thuy B TranDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Lauren M PostlewaitDepartment of Surgery, Emory University, Atlanta, GA, USA.
Shishir K MaithelDepartment of Surgery, Emory University, Atlanta, GA, USA.
Tracy S WangDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Douglas B EvansDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Ioannis HatzarasDepartment of Surgery, New York University School of Medicine, New York, NY, USA.
Rivfka ShenoyDepartment of Surgery, New York University School of Medicine, New York, NY, USA.
John E PhayDepartment of Surgery, The Ohio State University, Columbus, OH, USA.
Kara KeplingerDepartment of Surgery, The Ohio State University, Columbus, OH, USA.
Ryan C FieldsDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Lindsey E MosesDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Sharon M WeberDepartment of General Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Ahmed SalemDepartment of General Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Jason K SicklickDepartment of Surgery, University of California San Diego, San Diego, CA, USA.
Shady GadDepartment of Surgery, University of California San Diego, San Diego, CA, USA.
Adam C YoppDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
John C MansourDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Quan-Yang DuhDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Natalie SeiserDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Carmen C SolorzanoDepartment of Surgery, Vanderbilt University, Nashville, TN, USA.
Colleen M KiernanDepartment of Surgery, Vanderbilt University, Nashville, TN, USA.
Konstantinos I VotanopoulosDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Edward A LevineDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
George A PoultsidesDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Timothy M PawlikDepartment of Surgery, Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 688, Baltimore, MD 21287, USA.
Johns Hopkins Hospital · USEmory University · USMedical College of Wisconsin · USNew York University · USStanford University · USThe Ohio State University · USThe University of Texas Southwestern Medical Center · USUniversity of California, San Diego · USUniversity of California, San Francisco · USVanderbilt University · USWake Forest University · USWashington University in St. Louis · USJohns Hopkins University · USUniversity of Wisconsin–Madison · USWisconsin Division of Public Health · US

Funding

Novel Allosteric Kinase Inhibitors Target Imatinib-Resistant GISTK08CA168999 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2014 to 2018
$888k
Defining the Germline Genomic Landscape of a Novel GIST Multi-tumor SyndromeR21CA192072 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2016 to 2017
$399k
NCI NIH HHS K08 CA168999NCI NIH HHS R21 CA192072
6 · The paper itself

Abstract

backgroundThe association of postoperative complications with long-term oncologic outcomes remains unclear. We sought to determine the incidence of complications among patients who underwent surgery for adrenocortical carcinoma (ACC) and define the relationship of morbidity with long-term survival.

methodsPatients who underwent surgery for ACC between 1993 and 2014 were identified from 13 academic institutions participating in the US ACC group study. The incidence and type of the postoperative complications, the factors associated with them as well their association with long-term survival were analyzed.

resultsA total of 265 patients with median age of 52 years (IQR 44-63) were identified; at surgery, the majority of patients underwent an open abdominal procedure (n = 169, 66.8%). A postoperative complication occurred in 99 patients for a morbidity of 37.4%; five patients (1.9%) died in hospital. Factors associated with morbidity included a thoraco-abdominal operative approach (reference: open abdominal; OR 2.85, 95% CI 1.00-8.18), and a hormonally functional tumor (OR 3.56, 95% CI 1.65-7.69) (all P < 0.05). Presence of any complication was associated with a worse long-term outcome (median survival: no complication, 58.9 months vs. any complication, 25.1 months; P = 0.009). In multivariate analysis, after adjusting for patient- and disease-related factors postoperative infectious complications independently predicted shorter overall survival (hazard ratio (HR) 5.56, 95% CI 2.24-13.80; P < 0.001).

conclusionPostoperative complications were independently associated with decreased long-term survival after resection for ACC. The prevention of complications may be important from an oncologic perspective.

Indexed as

ForecastingAdrenal Cortex NeoplasmsAdrenalectomyAdrenocortical CarcinomaAdultFemaleHumansMaleMiddle AgedMorbidityPostoperative ComplicationsProportional Hazards ModelsUnited States

Identifiers

PMID26546184
PMCPMC4957940
OpenAlexW2150170713

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.