ArticleMolecular biology and evolution2016
Estimating the Ages of Selection Signals from Different Epochs in Human History.
Article in Molecular biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Evolutionary Origin of Ocular Melanoma: Associations With rs12913832 G Allele Frequency and Latitude.Cancer medicine · 2026Observational
- How Everything Is Connected to Everything Else - Population-Specific Connections between Adaptive Evolution, Disease Susceptibility, and Drug Responsiveness.Advanced genetics (Hoboken, N.J.) · 2025Article
- Why humans evolved blue eyes.Frontiers in psychology · 2025Article
- Genomic imputation of ancient Asian populations contrasts local adaptation in pre- and post-agricultural Japan.iScience · 2024Article
- Vitamin D in the Context of Evolution.Nutrients · 2022Review
- Article
- A vertebrate adaptive radiation is assembled from an ancient and disjunct spatiotemporal landscape.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Ancient RNA virus epidemics through the lens of recent adaptation in human genomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- A Likelihood Approach for Uncovering Selective Sweep Signatures from Haplotype Data.Molecular biology and evolution · 2020Article
- Evolutionary dynamics of recent selection on cognitive abilities.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Searching for Sympatric Speciation in the Genomic Era.BioEssays : news and reviews in molecular, cellular and developmental biology · 2019Review
- Inferring the model and onset of natural selection under varying population size from the site frequency spectrum and haplotype structure.Proceedings. Biological sciences · 2019Article
- Rapid evolution of a skin-lightening allele in southern African KhoeSan.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The transition to modernity and chronic disease: mismatch and natural selection.Nature reviews. Genetics · 2018Review
- Estimating Time to the Common Ancestor for a Beneficial Allele.Molecular biology and evolution · 2018Article
- Harnessing ancient genomes to study the history of human adaptation.Nature reviews. Genetics · 2017Review
- Accelerating Wright-Fisher Forward Simulations on the Graphics Processing Unit.G3 (Bethesda, Md.) · 2017Article
- A time transect of exomes from a Native American population before and after European contact.Nature communications · 2016Article
- Understanding rare and common diseases in the context of human evolution.Genome biology · 2016Review
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Authors and funding
7 authors.
Funding
Abstract
Genetic variation harbors signatures of natural selection driven by selective pressures that are often unknown. Estimating the ages of selection signals may allow reconstructing the history of environmental changes that shaped human phenotypes and diseases. We have developed an approximate Bayesian computation (ABC) approach to estimate allele ages under a model of selection on new mutations and under demographic models appropriate for human populations. We have applied it to two resequencing data sets: An ultra-high depth data set from a relatively small sample of unrelated individuals and a lower depth data set in a larger sample with transmission information. In addition to evaluating the accuracy of our method based on simulations, for each SNP, we assessed the consistency between the posterior probabilities estimated by the ABC approach and the ancient DNA record, finding good agreement between the two types of data and methods. Applying this ABC approach to data for eight single nucleotide polymorphisms (SNPs), we were able to rule out an onset of selection prior to the dispersal out-of-Africa for three of them and more recent than the spread of agriculture for an additional three SNPs.
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