Evidence map›Paper›PMID 26545907›Full record

ArticleClinical biochemistry2016

Oxidative stress is associated with weight gain in recipients at 12-months following kidney transplantation.

Young-Eun Cho, Hyung-Suk Kim, Chen Lai, Ansley Stanfill, Ann Cashion

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical biochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Bilirubin, a new therapeutic for kidney transplant?Transplantation reviews (Orlando, Fla.) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Young-Eun ChoNational Institute of Nursing Research, National Institutes of Health, 3 Center Drive, Building 3, Room 5E26, Bethesda, MD 20892-2178, USA. Electronic address: young-eun.cho@nih.gov.
Hyung-Suk KimNational Institute of Nursing Research, National Institutes of Health, 3 Center Drive, Building 3, Room 5E26, Bethesda, MD 20892-2178, USA. Electronic address: kimhy@mail.nih.gov.
Chen LaiNational Institute of Nursing Research, National Institutes of Health, 3 Center Drive, Building 3, Room 5E26, Bethesda, MD 20892-2178, USA. Electronic address: laichi@mail.nih.gov.
Ansley StanfillUniversity of Pittsburgh, 440 Victoria Building, 3500 Victoria St, Pittsburgh, PA 15261, USA. Electronic address: stanfill@pitt.edu.
Ann CashionNational Institute of Nursing Research, National Institutes of Health, 3 Center Drive, Building 3, Room 5E26, Bethesda, MD 20892-2178, USA. Electronic address: ann.cashion@nih.gov.

Funding

Genomic Approaches for Elucidating Novel Targets for Pain and Symptom ManagementZIANR000015 · NINR · NATIONAL INSTITUTE OF NURSING RESEARCH · PI KIM, HYUNG SUK · 2009 to 2021
$20.2M
Biomarkers to Predict Patient Outcomes and Guide TherapiesZIANR000030 · NINR · NATIONAL INSTITUTE OF NURSING RESEARCH · PI CASHION, ANN · 2014 to 2019
$10.0M
Genetics, Environment and Weight Gain PosttransplantR01NR009270 · NINR · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI HATHAWAY, DONNA K · 2007 to 2011
$1.7M
Intramural NIH HHS Z99 NR999999Intramural NIH HHS ZIA NR000030NINR NIH HHS R01 NR009270NINR NIH HHS R01NR009270
6 · The paper itself

Abstract

objectiveWeight gain after kidney transplantation (Tx) is considered a risk factor for poor outcomes. Increased oxidative stress is associated with not only chronic renal disease and Tx, but also obesity and cardiovascular disease. The aim of this pilot study was to test whether oxidative stress is related to weight gain at 12-months after kidney Tx and to obtain preliminary insight into potential mechanisms involved. DESIGN &

methodsRecipients (n=33) were classified into two groups; weight loss and weight gain, based on their weight changes at 12-months post-transplant. Total antioxidant capacity (TAOC) and lipid peroxidation (TBARS) were measured to evaluate oxidative stress from plasma at baseline and 12-months. A secondary data analysis was conducted to identify potential gene regulation.

resultsSeventeen recipients lost (-6.63±5.52kg), and sixteen recipients gained weight (8.94±6.18kg). TAOC was significantly decreased at 12-months compared to baseline for the total group, however, there was no significant difference between groups at either time point. TBARS was higher in weight gain group, at both time points, and it was significantly higher at 12-months (p=0.012). Gene expression profiling analysis showed that 7 transcripts annotated to reactive oxygen species related genes in adipose tissue were expressed significantly lower in weight gain group at baseline, which might be a negative feedback mechanism to reduce oxidative stress.

conclusionThese results may indicate that elevated oxidative stress (TBARS) is associated with weight gain after kidney Tx and that incorporating early clinical prevention strategies known to decrease oxidative stress could be recommended.

Indexed as

Kidney TransplantationAntioxidantsCardiovascular DiseasesCohort StudiesFemaleHumansKidneyKidney Failure, ChronicLipid PeroxidationMaleMiddle AgedObesityOxidative StressPilot ProjectsReactive Oxygen SpeciesRisk FactorsAntioxidantsReactive Oxygen SpeciesKidney transplantationOxidative stressWeight gain

Identifiers

PMID26545907
PMCPMC4744494

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.