Evidence map›Paper›PMID 26545748›Full record

ReviewAdvances in experimental medicine and biology2015

Dentin Matrix Proteins in Bone Tissue Engineering.

Sriram Ravindran, Anne George

Open access · greenAbstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
8.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Roles of calcium in ameloblasts during tooth development: A scoping review.Journal of Taibah University Medical Sciences · 2025
    Review
  7. Article
  8. DMP-1 expression in alveolar bone socket followingJournal of advanced veterinary and animal research · 2024
    Article
  9. Comparison of the osteogenic effects of demineralized dentin matrix and acellular dentin matrix.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024
    Article
  10. Review
  11. Dentin Particulate for Bone Regeneration: An In Vitro Study.International journal of molecular sciences · 2022
    Article
  12. Autogenous Tooth Bone Grafts for Repair and Regeneration of Maxillofacial Defects: A Narrative Review.International journal of environmental research and public health · 2022
    Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sriram RavindranBrodie Tooth Development Genetics & Regenerative Medicine Research Laboratory Department of Oral Biology, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Anne GeorgeBrodie Tooth Development Genetics & Regenerative Medicine Research Laboratory Department of Oral Biology, University of Illinois at Chicago, Chicago, IL, 60612, USA. anneg@uic.edu.
University of Illinois Chicago · US

Funding

CHARACTERIZATION OF DMP1--DENTIN PHOSPHOPROTEINR01DE011657 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GEORGE, ANNE · 1996 to 2018
$5.2M
Intracellular and Extracellular function of dentin phosphophorynR01DE019633 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GEORGE, ANNE · 2010 to 2013
$1.5M
Characterization of DMP1 a dentin phosphoproteinR56DE011657 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GEORGE, ANNE · 2008 to 2008
$341k
NIDCR NIH HHS DE 11657NIDCR NIH HHS DE 19633NIDCR NIH HHS R01 DE011657NIDCR NIH HHS R01 DE019633NIDCR NIH HHS R56 DE011657
6 · The paper itself

Abstract

Dentin and bone are mineralized tissue matrices comprised of collagen fibrils and reinforced with oriented crystalline hydroxyapatite. Although both tissues perform different functionalities, they are assembled and orchestrated by mesenchymal cells that synthesize both collagenous and noncollagenous proteins albeit in different proportions. The dentin matrix proteins (DMPs) have been studied in great detail in recent years due to its inherent calcium binding properties in the extracellular matrix resulting in tissue calcification. Recent studies have shown that these proteins can serve both as intracellular signaling proteins leading to induction of stem cell differentiation and also function as nucleating proteins in the extracellular matrix. These properties make the DMPs attractive candidates for bone and dentin tissue regeneration. This chapter will provide an overview of the DMPs, their functionality and their proven and possible applications with respect to bone tissue engineering.

Indexed as

Bone and BonesCalcification, PhysiologicCalciumDentinExtracellular Matrix ProteinsHumansPhosphoproteinsProtein IsoformsRegenerationTissue EngineeringCalciumExtracellular Matrix ProteinsPhosphoproteinsProtein IsoformsBone regenerationDentin matrix proteinsDMP1DMP4DPPDSPFAM20CTissue engineering

Identifiers

PMID26545748
PMCPMC4755351
OpenAlexW2281431891

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.