ArticleMechanisms of development2015
Insm1 promotes neurogenic proliferation in delaminated otic progenitors.
Article in Mechanisms of development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Insulinoma-associated 1 promotes neurogenic proliferation of cortical basal progenitors but is largely dispensable for projection neuron production.bioRxiv : the preprint server for biology · 2026Article
- Pou4f3 Deficiency Obstructs the Subtype Differentiation of Vestibular Hair Cells.Neuroscience bulletin · 2026Article
- Engineering of functional auditory neurons from human induced pluripotent stem cells.Military Medical Research · 2026Article
- Early and transient requirements for FGFR2b/1b ligands in cochlear sensory and neural cell subtype differentiation.Developmental biology · 2025Article
- Targeted cell interconversions reveal inner hair cell control of organ of Corti cytoarchitecture.Science advances · 2025Article
- Differential Chromatin Accessibility, Gene Expression, and mRNA Splicing Between Developing Cochlear Inner and Outer Hair Cells.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- prdm1a drives a fate switch between hair cells of different mechanosensory organs.Nature communications · 2025Article
- Article
- Irx3/5 Null Deletion in Mice Blocks Cochlea-Saccule Segregation and Disrupts the Auditory Tonotopic Map.The Journal of comparative neurology · 2024Article
- Revisiting the Potency of Tbx2 Expression in Transforming Outer Hair Cells into Inner Hair Cells at Multiple Ages In Vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Identification of multiple transcription factor genes potentially involved in the development of electrosensoryFrontiers in cell and developmental biology · 2024Article
- Fgf8Neuroscience bulletin · 2023Article
- Article
- Early Steps towards Hearing: Placodes and Sensory Development.International journal of molecular sciences · 2023Review
- TBX2 specifies and maintains inner hair and supporting cell fate in the Organ of Corti.Nature communications · 2022Article
- Article
- Regenerated hair cells in the neonatal cochlea are innervated and the majority co-express markers of both inner and outer hair cells.Frontiers in cellular neuroscience · 2022Article
- Neurosensory development of the four brainstem-projecting sensory systems and their integration in the telencephalon.Frontiers in neural circuits · 2022Article
- Cochlear Development; New Tools and Approaches.Frontiers in cell and developmental biology · 2022Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
INSM1 is a zinc-finger protein expressed throughout the developing nervous system in late neuronal progenitors and nascent neurons. In the embryonic cortex and olfactory epithelium, Insm1 may promote the transition of progenitors from apical, proliferative, and uncommitted to basal, terminally-dividing and neuron producing. In the otocyst, delaminating and delaminated progenitors express Insm1, whereas apically-dividing progenitors do not. This expression pattern is analogous to that in embryonic olfactory epithelium and cortex (basal/subventricular progenitors). Lineage analysis confirms that auditory and vestibular neurons originate from Insm1-expressing cells. In the absence of Insm1, otic ganglia are smaller, with 40% fewer neurons. Accounting for the decrease in neurons, delaminated progenitors undergo fewer mitoses, but there is no change in apoptosis. We conclude that in the embryonic inner ear, Insm1 promotes proliferation of delaminated neuronal progenitors and hence the production of neurons, a similar function to that in other embryonic neural epithelia. Unexpectedly, we also found that differentiating, but not mature, outer hair cells express Insm1, whereas inner hair cells do not. Insm1 is the earliest known gene expressed in outer versus inner hair cells, demonstrating that nascent outer hair cells initiate a unique differentiation program in the embryo, much earlier than previously believed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.