Trial reportJournal of pediatric gastroenterology and nutrition2016
Probiotic Administration in Infants With Gastroschisis: A Pilot Randomized Placebo-Controlled Trial.
Trial report in Journal of pediatric gastroenterology and nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Probiotics for the postoperative management of term neonates after gastrointestinal surgery.The Cochrane database of systematic reviews · 2024Pooled it
- Probiotic supplementation in neonates with congenital gastrointestinal surgical conditions: a pilot randomised controlled trial.Pediatric research · 2022Trial
- Gut microbial differences and function in infants with gastroschisis: a pilot prospective cohort study.Beneficial microbes · 2026Article
- Perioperative Probiotic Supplementation to Reduce Postoperative Infection and Inflammation in Children and Neonates Undergoing Gastrointestinal Surgery: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2026Review
- Microbiota-Modulating Strategies in Neonates Undergoing Surgery for Congenital Gastrointestinal Conditions: A Narrative Review.Nutrients · 2025Review
- Feeding practices for infants with gastroschisis: A survey of neonatal intensive care units in Canada.Journal of neonatal-perinatal medicine · 2025Article
- A 36-week preterm newborn with gastroschisis: a rare case report.Journal of surgical case reports · 2025Article
- Individual and Combined Effects of 2'-Fucosyllactose and Bifidobacterium longum subsp. infantis on the Gut Microbiota Composition of Piglets.The Journal of nutrition · 2025Article
- Impact ofNutrients · 2024Review
- Safety, efficacy, and impact on gut microbial ecology of aFrontiers in nutrition · 2023Article
- Probiotic supplementation for neonates with congenital gastrointestinal surgical conditions: guidelines for future research.Pediatric research · 2023Review
- The Potential of Probiotics to Eradicate Gut Carriage of Pathogenic or Antimicrobial-ResistantAntibiotics (Basel, Switzerland) · 2021Review
- Impact of Clinical Factors on the Intestinal Microbiome in Infants With Gastroschisis.JPEN. Journal of parenteral and enteral nutrition · 2021Article
- Gut microbiota in neonates with congenital gastrointestinal surgical conditions: a prospective study.Pediatric research · 2020Article
- Review
- Probiotic research in neonates with congenital gastrointestinal surgical conditions - Now is the time.Microbial biotechnology · 2019Article
- Review
- Efficacy ofGut microbesReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesInfants with gastroschisis often require long periods of gastric suctioning and hospitalization. The impact of these interventions on the intestinal microbiota and attempts to alter the microbial community have not been studied. We sought to determine how the intestinal microbiota is influenced by the current treatment of gastroschisis and whether alteration of the intestinal microbiota with a probiotic microbe will influence length of hospitalization.
methodsWe performed a randomized, placebo-controlled pilot study of administration of probiotic Bifidobacterium longum subsp. infantis in 24 infants with gastroschisis. The primary outcome was changes in the fecal microbiota, and the secondary outcome was length of hospital stay.
resultsAdministration of the probiotic or placebo was well tolerated, even during the period of gastric suctioning. The overall microbial communities were not significantly different between groups, although analysis of the final specimens by family demonstrated higher Bifidobacteriaceae, lower Clostridiaceae, and trends toward lower Enterobacteriaceae, Enterococcaceae, Staphylococcaceae, and Streptococcaceae in the probiotic group. Clinical outcomes, including length of hospital stay, did not differ between groups.
conclusionsIn this pilot study, there was significant in infants with gastroschisis that was partially attenuated by the administration of B longum subsp. infantis.
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