Evidence map›Paper›PMID 26545029›Full record

ArticleEnvironmental health perspectives2016

Computational Exposure Science: An Emerging Discipline to Support 21st-Century Risk Assessment.

Peter P Egeghy, Linda S Sheldon, Kristin K Isaacs, Halûk Özkaynak, Michael-Rock Goldsmith, John F Wambaugh, Richard S Judson, Timothy J Buckley

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 88 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Exposure forecasting - ExpoCast - for data-poor chemicals in commerce and the environment.Journal of exposure science & environmental epidemiology · 2022
    Review
  6. Article
  7. Review
  8. Article
  9. Quo vadis blood protein adductomics?Archives of toxicology · 2022
    Review
  10. Article
  11. Article
  12. Evolving Science and Practice of Risk Assessment.Risk analysis : an official publication of the Society for Risk Analysis · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. New Approach Methodologies for Exposure Science.Current opinion in toxicology · 2019
    Article
  18. Integrating exposure to chemicals in building materials during use stage.The international journal of life cycle assessment · 2019
    Article
  19. The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency.Toxicological sciences : an official journal of the Society of Toxicology · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Peter P EgeghyOffice of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.
Linda S Sheldon
Kristin K Isaacs
Halûk Özkaynak
Michael-Rock Goldsmith
John F Wambaugh
Richard S Judson
Timothy J Buckley
Environmental Protection Agency · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComputational exposure science represents a frontier of environmental science that is emerging and quickly evolving.

objectivesIn this commentary, we define this burgeoning discipline, describe a framework for implementation, and review some key ongoing research elements that are advancing the science with respect to exposure to chemicals in consumer products. DISCUSSION: The fundamental elements of computational exposure science include the development of reliable, computationally efficient predictive exposure models; the identification, acquisition, and application of data to support and evaluate these models; and generation of improved methods for extrapolating across chemicals. We describe our efforts in each of these areas and provide examples that demonstrate both progress and potential.

conclusionsComputational exposure science, linked with comparable efforts in toxicology, is ushering in a new era of risk assessment that greatly expands our ability to evaluate chemical safety and sustainability and to protect public health. CITATION: Egeghy PP, Sheldon LS, Isaacs KK, Özkaynak H, Goldsmith M-R, Wambaugh JF, Judson RS, Buckley TJ. 2016. Computational exposure science: an emerging discipline to support 21st-century risk assessment. Environ Health Perspect 124:697-702; http://dx.doi.org/10.1289/ehp.1509748.

Indexed as

Computer SimulationComputational BiologyEnvironmental ExposureEnvironmental PollutantsEnvironmental PollutionHumansRisk AssessmentUnited StatesUnited States Environmental Protection AgencyEnvironmental Pollutants

Identifiers

PMID26545029
PMCPMC4892918
OpenAlexW2413677068

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.