Evidence map›Paper›PMID 26544943›Full record

ArticleCell2015

Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.

Amy W Chung, Manu P Kumar, Kelly B Arnold, Wen Han Yu, Matthew K Schoen, Laura J Dunphy, Todd J Suscovich, Nicole Frahm, Caitlyn Linde, Alison E Mahan and 12 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05162482 (Immunogenicity and Safety of Heterologous Combinations of COVID-19 Vaccines Available Under Emergency Use Authorization in Pakistan), which is not on this map. Cited by 269 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
269citing papers in PubMed, 1 pooled it
19.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05162482 phase2unknown statusnot on this mapstarted 2022, after this paper: background citation

Immunogenicity and Safety of Heterologous Combinations of COVID-19 Vaccines Available Under Emergency Use Authorization in Pakistan: A Randomized Phase II Trial

TypeinterventionalSponsorAga Khan University Hospital, PakistanRan2022 to 2024Enrolled1,680ConditionsCOVID 19 VaccineArmsBIBP (CNBG, Sinopharm) WIV, CanSinoBIO, AstraZeneca ChAdOx
3 · Its place in the literature

Who cites it

269 citing papers in PubMed, 1 synthesis or guideline pooled it, 353 citations in OpenAlex.

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209 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 11 institutions in 5 countries.

Amy W ChungRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Parkville, VIC 3010, Australia.
Manu P KumarDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Kelly B ArnoldDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Wen Han YuRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Matthew K SchoenRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Laura J DunphyDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Todd J SuscovichRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Nicole FrahmFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Caitlyn LindeRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Alison E MahanRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Michelle HoffnerRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Hendrik StreeckDepartment of Molecular Virology and Pathogenesis, Walter Reed Army Institute of Research, U.S. Military HIV Research Program, Silver Spring, MD 20910, USA; Institute for Medical Biology, University Hospital Essen, University Duisburg-Essen, Essen 45141, Germany.
Margaret E AckermanThayer School of Engineering at Dartmouth, Hanover, NH 03755, USA.
M Juliana McElrathFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Hanneke SchuitemakerCrucell Holland B.V., The Janssen Pharmaceutical Companies of Johnson & Johnson, Leiden 2333, the Netherlands.
Maria G PauCrucell Holland B.V., The Janssen Pharmaceutical Companies of Johnson & Johnson, Leiden 2333, the Netherlands.
Lindsey R BadenRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02215, USA.
Jerome H KimDepartment of Molecular Virology and Pathogenesis, Walter Reed Army Institute of Research, U.S. Military HIV Research Program, Silver Spring, MD 20910, USA; International Vaccine Institute, Seoul 151-742, Republic of Korea.
Nelson L MichaelDepartment of Molecular Virology and Pathogenesis, Walter Reed Army Institute of Research, U.S. Military HIV Research Program, Silver Spring, MD 20910, USA.
Dan H BarouchRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Douglas A LauffenburgerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: lauffen@mit.edu.
Galit AlterRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address: galter@mgh.harvard.edu.
Ragon Institute of MGH, MIT and Harvard · USMassachusetts Institute of Technology · USFred Hutch Cancer Center · USJanssen (Netherlands) · NLBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USDartmouth College · USInternational Vaccine Institute · KRThe University of Melbourne · AUUniversity of Duisburg-Essen · DEWalter Reed Army Institute of Research · US

Funding

LOC: HIV Vaccine Trials NetworkUM1AI068614 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Dan H. Barouch, Lawrence Corey · 2011 to 2026
$1175.6M
LC: HIV Vaccine Trials NetworkUM1AI068618 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Margaret Juliana McElrath · 2011 to 2026
$483.6M
Demystifying the antiviral activity of the IgG3+ antibody responseR01AI080289 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI JUELG, BORIS DOMINIK · 2009 to 2024
$4.1M
NIAID NIH HHS R01 AI080289NIAID NIH HHS UM1 AI068614NIAID NIH HHS UM1 AI068618
6 · The paper itself

Abstract

While antibody titers and neutralization are considered the gold standard for the selection of successful vaccines, these parameters are often inadequate predictors of protective immunity. As antibodies mediate an array of extra-neutralizing Fc functions, when neutralization fails to predict protection, investigating Fc-mediated activity may help identify immunological correlates and mechanism(s) of humoral protection. Here, we used an integrative approach termed Systems Serology to analyze relationships among humoral responses elicited in four HIV vaccine trials. Each vaccine regimen induced a unique humoral "Fc fingerprint." Moreover, analysis of case:control data from the first moderately protective HIV vaccine trial, RV144, pointed to mechanistic insights into immune complex composition that may underlie protective immunity to HIV. Thus, multi-dimensional relational comparisons of vaccine humoral fingerprints offer a unique approach for the evaluation and design of novel vaccines against pathogens for which correlates of protection remain elusive.

Indexed as

AIDS VaccinesAnimalsAntibodies, ViralAntibody-Dependent Cell CytotoxicityAntigen-Antibody ComplexClinical Trials as TopicDrug DesignHIV InfectionsHumansImmunoglobulin GReceptors, FcAIDS VaccinesAntibodies, ViralAntigen-Antibody ComplexImmunoglobulin GReceptors, Fc

Identifiers

PMID26544943
PMCPMC5490491
OpenAlexW2105208620

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.