ArticleJournal of the American Chemical Society2015
Syntheses of Dimeric Tetrahydroxanthones with Varied Linkages: Investigation of "Shapeshifting" Properties.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Identification of natural products and synthetic analogs which inhibit microsporidia spores and prevent infection.Journal of invertebrate pathology · 2026Article
- Extracting Value from Marine and Microbial Natural Product Artifacts and Chemical Reactivity.Marine drugs · 2025Review
- Xanthone Dimers in Angiosperms, Fungi, Lichens: Comprehensive Review of Their Sources, Structures, and Pharmacological Properties.Molecules (Basel, Switzerland) · 2025Review
- Aculeaxanthones A-E, new xanthones from the marine-derived fungusFrontiers in microbiology · 2023Article
- New dimeric chromanone derivatives from the mutant strains ofRSC advances · 2022Article
- Asymmetric synthesis of chromanone lactonesChemical science · 2022Article
- Amycolachromones A-F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine ActinomyceteMarine drugs · 2022Article
- Enantioselective total synthesis of parnafungin A1 and 10a-Chemical science · 2021Article
- Robust, Enantioselective Construction of Challenging, Biologically Relevant Tertiary Ether Stereocenters.ACS catalysis · 2021Article
- Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite.Biomolecules · 2020Article
- Copper Bis(oxazoline)-Catalyzed Enantioselective Alkynylation of Benzopyrylium Ions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Synthesis and Anticancer Activity of Structure Simplified Naturally-Inspired Dimeric Chromenone Derivatives.European journal of organic chemistry · 2019Article
- Isolation of 4,4'-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma.The Journal of antibiotics · 2019Article
- Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling.Journal of the American Chemical Society · 2018Article
- The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane.Cell death & disease · 2018Article
- A 2,4'-linked tetrahydroxanthone dimer with protein tyrosine phosphatase 1B inhibitory activity from the Okinawan freshwater Aspergillus sp.The Journal of antibiotics · 2017Article
- Photoredox-Mediated Routes to Radicals: The Value of Catalytic Radical Generation in Synthetic Methods Development.ACS catalysis · 2017Review
- Organocatalyzed, Photoredox Heteroarylation of 2-Trifluoroboratochromanones via C-H Functionalization.Organic letters · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The 2,4'- and 4,4'-linked variants of the cytotoxic agent secalonic acid A and their analogues have been synthesized. Kinetic resolution of an unprotected tetrahydroxanthone scaffold followed by copper-mediated biaryl coupling allowed for efficient access to these compounds. Evaluation of the "shapeshifting" properties of 2,2'-, 2,4'-, and 4,4'-linked variants of the secalonic acids A in a polar solvent in conjunction with assays of the compounds against select cancer cell lines was conducted to study possible correlations between linkage variation and cytotoxicity.
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