Evidence map›Paper›PMID 26544619›Full record

ArticleJournal of affective disorders2016

The relationship between anxiety disorders and dimensional representations of DSM-IV personality disorders: A co-twin control study.

A Welander-Vatn, E Ystrom, K Tambs, M C Neale, K S Kendler, T Reichborn-Kjennerud, G P Knudsen

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Personality disorders in cluster headache: a study using the Millon Clinical Multiaxial Inventory-III.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

A Welander-VatnDepartment of Genetics, Environment and Mental Health, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway. Electronic address: auwe@fhi.no.
E YstromDepartment of Genetics, Environment and Mental Health, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway; Department of Psychology, Faculty of Social Sciences, University of Oslo, Norway.
K TambsDepartment of Genetics, Environment and Mental Health, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway.
M C NealeVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
K S KendlerVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
T Reichborn-KjennerudDepartment of Genetics, Environment and Mental Health, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway.
G P KnudsenDepartment of Genetics, Environment and Mental Health, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway.
Norwegian Institute of Public Health · NOVirginia Commonwealth University · USUniversity of Oslo · NO

Funding

Psychopathology: Models, measurement and classificationR01MH065322 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEALE, MICHAEL CHURTON · 2003 to 2007
$2.0M
Axis I &Axis II Psychiatric Disorders in Norwegian TwinR01MH068643 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI KENDLER, KENNETH SEEDMAN · 2004 to 2007
$1.2M
NIMH NIH HHS MH-068643NIMH NIH HHS MH-65322NIMH NIH HHS R01 MH065322NIMH NIH HHS R01 MH068643
6 · The paper itself

Abstract

backgroundThere is substantial comorbidity between personality disorders (PDs) and anxiety disorders (ADs). Sharing of familial risk factors possibly explains the co-occurrence, but direct causal relationships between the disorders may also exist.

methods2801 persons from 1391 twin pairs from the Norwegian Institute of Public Health Twin Panel were assessed for all DSM-IV PDs and ADs. Bivariate Poisson-regression analyses were performed to assess whether PDs predicted ADs at three different levels: All PDs combined, PDs combined within DSM-IV-clusters and each individual PD separately. Next, bivariate co-twin control analyses were executed within monozygotic (MZ) and dizygotic (DZ) twin pairs. A similar analytic strategy was employed in multivariate models including PDs as independent variables.

resultsPDs predicted ADs at all levels of analysis in bivariate regression models. Bivariate co-twin control analyses demonstrated an increased risk of ADs in all PDs combined, all PD-clusters and in schizotypal, paranoid, borderline, antisocial, avoidant and dependent PD. In the multivariate regression model, all PD-clusters and schizotypal, borderline, avoidant and obsessive-compulsive PD predicted ADs. Only borderline and avoidant PD predicted ADs in the multivariate co-twin control analysis. LIMITATIONS: Over-adjustment may explain the results from the multivariate analyses. The cross-sectional study design hampers causal inference.

conclusionsComorbidity between ADs and PDs can be largely accounted for by shared familial risk factors. However, the results are also consistent with a direct causal relationship partly explaining the co-occurrence. Our results indicate specific environmental factors for comorbidity of ADs and borderline and avoidant PDs that are not shared with other PDs.

Indexed as

AdultAntisocial Personality DisorderAnxiety DisordersComorbidityCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersDiseases in TwinsFemaleHumansMaleMultivariate AnalysisNorwayParanoid Personality DisorderPersonality DisordersRegression AnalysisRisk FactorsAnxiety disordersComorbidityCo-twin control designGenetic epidemiologyPersonality DisordersTwin study

Identifiers

PMID26544619
PMCPMC4684968
OpenAlexW1803495217

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.