Evidence map›Paper›PMID 26544615›Full record

Trial reportJournal of affective disorders2016

Ongoing life stressors and suicidal ideation among HIV-infected adults with depression.

Julie K O'Donnell, Bradley N Gaynes, Stephen R Cole, Andrew Edmonds, Nathan M Thielman, E Byrd Quinlivan, Kristen Shirey, Amy D Heine, Riddhi Modi, Brian W Pence

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julie K O'DonnellUniversity of North Carolina at Chapel Hill, Department of Epidemiology, United States. Electronic address: julie.k.odonnell@gmail.com.
Bradley N GaynesUniversity of North Carolina at Chapel Hill School of Medicine, Department of Psychiatry, United States.
Stephen R ColeUniversity of North Carolina at Chapel Hill, Department of Epidemiology, United States.
Andrew EdmondsUniversity of North Carolina at Chapel Hill, Department of Epidemiology, United States.
Nathan M ThielmanDuke University, Center for Health Policy, Duke Global Health Institute, United States.
E Byrd QuinlivanUniversity of North Carolina at Chapel Hill, Institute for Global Health, Infectious Diseases and Center for AIDS Research, United States.
Kristen ShireyDuke University School of Medicine, Department of Psychiatry, United States.
Amy D HeineUniversity of North Carolina at Chapel Hill, Institute for Global Health and Infectious Diseases, United States.
Riddhi ModiUniversity of Alabama at Birmingham, Division of Infectious Diseases, United States.
Brian W PenceUniversity of North Carolina at Chapel Hill, Department of Epidemiology, United States.

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Training in Infectious Disease Epidemiology (TIDE)T32AI070114 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian W Pence · 2007 to 2026
$4.0M
Improving HAART Adherence in Depressed HIV Clinic Patients: A Real-World RCTR01MH086362 · NIMH · DUKE UNIVERSITY · PI PENCE, BRIAN W · 2009 to 2013
$3.5M
NIAID NIH HHS 5T32AI070114-08NIAID NIH HHS P30 AI027767NIAID NIH HHS P30-AI027767NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI064518NIAID NIH HHS P30-AI064518NIAID NIH HHS P30-AI50410NIAID NIH HHS T32 AI070114NIMH NIH HHS R01 MH086362NIMH NIH HHS R01MH086362
6 · The paper itself

Abstract

backgroundSuicidal ideation is the most proximal risk factor for suicide and can indicate extreme psychological distress; identification of its predictors is important for possible intervention. Depression and stressful or traumatic life events (STLEs), which are more common among HIV-infected individuals than the general population, may serve as triggers for suicidal thoughts.

methodsA randomized controlled trial testing the effect of evidence-based decision support for depression treatment on antiretroviral adherence (the SLAM DUNC study) included monthly assessments of incident STLEs, and quarterly assessments of suicidal ideation (SI). We examined the association between STLEs and SI during up to one year of follow-up among 289 Southeastern US-based participants active in the study between 7/1/2011 and 4/1/2014, accounting for time-varying confounding by depressive severity with the use of marginal structural models.

resultsParticipants were mostly male (70%) and black (62%), with a median age of 45 years, and experienced a mean of 2.36 total STLEs (range: 0-12) and 0.48 severe STLEs (range: 0-3) per month. Every additional STLE was associated with an increase in SI prevalence of 7% (prevalence ratio (PR) (95% confidence interval (CI)): 1.07 (1.00, 1.14)), and every additional severe STLE with an increase in SI prevalence of 19% (RR (95% CI): 1.19 (1.00, 1.42)). LIMITATIONS: There was a substantial amount of missing data and the exposures and outcomes were obtained via self-report; methods were tailored to address these potential limitations.

conclusionsSTLEs were associated with increased SI prevalence, which is an important risk factor for suicide attempts and completions.

Indexed as

Suicidal IdeationAdultAttitude to HealthDepressionFemaleHIV InfectionsHumansMaleMiddle AgedPrevalenceRisk FactorsStress, PsychologicalSuicideSuicide, AttemptedUnited StatesDepressionHIVStressSuicidal ideationTrauma

Identifiers

PMID26544615
PMCPMC4685465

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.