ArticlePloS one2015
The Effect of Axial Length on the Thickness of Intraretinal Layers of the Macula.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Sector-Specific Patterns of RNFL and Ganglion Cell Complex Thinning Across the Myopia Spectrum: A Cross-Sectional OCTA Study.Medicina (Kaunas, Lithuania) · 2026Article
- Macular, Foveal and RNFL Thickness Patterns in Amblyopia: A Comparative Study.Clinical optometry · 2026Article
- Optic Nerve Head Morphology and Macula Ganglion Cell Inner Plexiform Layer Thickness in Axially Anisometropic Rhesus Monkeys.Investigative ophthalmology & visual science · 2024Article
- Morphological and Clinical Characterization of Foveal Bulge Sign Three Years After Retinal Detachment Repair: A Longitudinal Prospective Evaluation.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Prediction of visual field defects from macular optical coherence tomography in glaucoma using cluster analysis.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2022Article
- Identifying the Retinal Layers Linked to Human Contrast Sensitivity Via Deep Learning.Investigative ophthalmology & visual science · 2022Article
- Spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology.PloS one · 2022Article
- The assessment of acute chorioretinal changes due to intensive physical exercise in young adults.PloS one · 2022Article
- Association of Birth Weight With Foveolar Thickness in Adulthood: Results From a Population-Based Study.Investigative ophthalmology & visual science · 2021Article
- Neuroretinal Biomarkers for Schizophrenia Spectrum Disorders.Translational vision science & technology · 2021Article
- The Influence of Axial Length Upon the Retinal Ganglion Cell Layer of the Human Eye.Translational vision science & technology · 2020Article
- Association of macular thickness with parapapillary atrophy in myopic eyes.BMC ophthalmology · 2020Article
- A recommended "minimum data set" framework for SD-OCT retinal image acquisition and analysis from the Atlas of Retinal Imaging in Alzheimer's Study (ARIAS).Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Identification of Retinal Biomarkers in Alzheimer's Disease Using Optical Coherence Tomography: Recent Insights, Challenges, and Opportunities.Journal of clinical medicine · 2019Review
- Retinal Layer Thicknesses in Early Age-Related Macular Degeneration: Results From the German AugUR Study.Investigative ophthalmology & visual science · 2019Article
- RE-PERG, a new paradigm for glaucoma diagnosis, in myopic eyes.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- Assessing reproducibility and the effects of demographic variables on the normal macular layers using the Spectralis SD-OCT.Clinical ophthalmology (Auckland, N.Z.) · 2018Article
- Retinal thinning is uniquely associated with medial temporal lobe atrophy in neurologically normal older adults.Neurobiology of aging · 2017Article
- A morphological study of retinal changes in unilateral amblyopia using optical coherence tomography image segmentation.PloS one · 2014Article
- Macular thickness analysis for glaucoma diagnosis and management.Taiwan journal of ophthalmologyReview
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeThe aim of this study was to evaluate the effect of axial length (AL) on the thickness of intraretinal layers in the macula using optical coherence tomography (OCT) image analysis.
methodsFifty three randomly selected eyes of 53 healthy subjects were recruited for this study. The median age of the participants was 29 years (range: 6 to 67 years). AL was measured for each eye using a Lenstar LS 900 device. OCT imaging of the macula was also performed by Stratus OCT. OCTRIMA software was used to process the raw OCT scans and to determine the weighted mean thickness of 6 intraretinal layers and the total retina. Partial correlation test was performed to assess the correlation between the AL and the thickness values.
resultsTotal retinal thickness showed moderate negative correlation with AL (r = -0.378, p = 0.0007), while no correlation was observed between the thickness of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCC), retinal pigment epithelium (RPE) and AL. Moderate negative correlation was observed also between the thickness of the ganglion cell layer and inner plexiform layer complex (GCL+IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL) and AL which were more pronounced in the peripheral ring (r = -0.402, p = 0.004; r = -0.429, p = 0.002; r = -0.360, p = 0.01; r = -0.448, p = 0.001).
conclusionsOur results have shown that the thickness of the nuclear layers and the total retina is correlated with AL. The reason underlying this could be the lateral stretching capability of these layers; however, further research is warranted to prove this theory. Our results suggest that the effect of AL on retinal layers should be taken into account in future studies.
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