Evidence map›Paper›PMID 26544193›Full record

ArticlePloS one2015

Human Salivary Micro-RNA in Patients with Parotid Salivary Gland Neoplasms.

Johannes H Matse, Janice Yoshizawa, Xiaoyan Wang, David Elashoff, Jan G M Bolscher, Enno C I Veerman, C René Leemans, D Michiel Pegtel, Michiel D Pegtel, David T W Wong and 1 more

Erratum issuedOpen access · goldAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Human salivary microRNAs in Cancer.Journal of Cancer · 2018
    Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Johannes H MatseDepartment of Oral and Maxillofacial Surgery and Oral Pathology, VU University medical center / Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
Janice YoshizawaSchool of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, California, United States of America.
Xiaoyan WangStatistics Core, UCLA David Geffen School of Medicine, Division of General Internal Medicine and Health Services Research, University of California Los Angeles, Los Angeles, California, United States of America.
David ElashoffStatistics Core, UCLA David Geffen School of Medicine, Division of General Internal Medicine and Health Services Research, University of California Los Angeles, Los Angeles, California, United States of America.
Jan G M BolscherDepartment of Oral Biochemistry ACTA, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.
Enno C I VeermanDepartment of Oral Biochemistry ACTA, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.
C René LeemansDepartment of Otolaryngology, VU University medical center, Amsterdam, The Netherlands.
D Michiel Pegtel
Michiel D PegtelDepartment of Pathology, VU University medical center, Amsterdam, The Netherlands.
David T W WongSchool of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, California, United States of America.
Elisabeth BloemenaDepartment of Oral and Maxillofacial Surgery and Oral Pathology, VU University medical center / Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
University of California, Los Angeles · USAmsterdam UMC Location VUmc · NLAcademic Center for Dentistry Amsterdam · NLUniversity of Amsterdam · NL

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
NCATS NIH HHS UL1 TR000124
6 · The paper itself

Abstract

backgroundCurrently, clinical examination, ultrasound scanning (with or without fine needle aspiration cytology), preoperative CT-scan and MRI are available for the differential diagnosis of parotid gland swelling. A preliminary non-invasive salivary diagnostic tool may be helpful in the clinical decision making process. Altered salivary micro-RNA (miRNA) expression levels have been observed in saliva from patients with various cancers. Therefore, we investigated miRNA expression levels in saliva samples from patients with a parotid gland neoplasm using Human miRNA cards in comparison to controls.

resultsIn the discovery phase, eight miRNAs were identified having different expression levels in patients compared to controls. In the validation phase, the differences in miRNA expression levels between patients and controls were confirmed for seven out of eight discovered miRNAs (p < 0.001). A combination of two miRNAs yielded a receiver-operator-characteristics curve with an AUC of 0.94 (95% CI: 0.87-1.00; sensitivity 91%; specificity 86%). Validation of discovered miRNAs in segregated collected parotid saliva revealed that expression of these miRNAs differ between whole saliva and parotid saliva.

conclusionsA two miRNA combination can predict the presence of a parotid gland neoplasm. Furthermore, this study suggested that the identified, patient-specific, salivary miRNAs were not derived from the parotid gland itself.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCytodiagnosisFemaleGene Expression Regulation, NeoplasticHumansMaleMicroRNAsMiddle AgedParotid GlandParotid NeoplasmsSalivaBiomarkers, TumorMicroRNAs

Identifiers

PMID26544193
PMCPMC4636154
OpenAlexW2227049856

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.