ArticleEpilepsy & behavior case reports2015
Reactivation of herpes simplex virus-1 following epilepsy surgery.
Article in Epilepsy & behavior case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Virus reactivation in acute and long COVID-19.Nature · 2026Article
- Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19.bioRxiv : the preprint server for biology · 2024Article
- Viral infections and their relationship to neurological disorders.Archives of virology · 2021Review
- Relapse of Herpes Simplex Encephalitis by Epilepsy Surgery 35 Years after the First Infection: A Case Report and Literature Review.NMC case report journal · 2021Article
- HSV-1 encephalitis relapse after epilepsy surgery: a case report and review of the literature.Journal of neurovirology · 2020Review
- Outcomes with acyclovir treatment in herpes simplex encephalitis after surgery for solid CNS tumors: a case report and systematic review of the literature.Neuro-oncology practice · 2019Article
- HSV-Encephalitis Reactivation after Cervical Spine Surgery.Case reports in surgery · 2019Article
- Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer's Disease.Frontiers in aging neuroscience · 2018Review
- Herpes Simplex Encephalitis: an Update.Current infectious disease reports · 2017Review
- Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a review.Dementia & neuropsychologiaReview
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe present study reports a case of encephalitis due to herpes simplex virus-1 (HSV-1), following surgical manipulation of the site of a primary infection.
methodsHerpes simplex virus-1 infection was confirmed by CSF PCR and DNA sequencing.
resultsThe patient was an 11-year-old girl who required temporal lobe surgery for epilepsy. She had meningoencephalitis due to HSV at the age of 20 months, and she was treated with acyclovir. Three years later, the patient developed uncontrolled seizures that became more frequent and changed in character at 11 years of age. On the 12th postoperative day, she developed fever and seizures, and she was diagnosed with HSV-1 by positive CSF PCR. She was treated with acyclovir (30 mg/kg/day for 21 days). In this report, we describe the patient and review the relevant literature.
conclusionThe authors stress the potential risk of reactivation of HSV encephalitis after intracranial surgery. Herpes simplex virus encephalitis must be considered in neurosurgical patients who develop postoperative seizures and fever.
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Registered trials
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