ArticleSpringerPlus2015
No association between Helicobacter pylori infection and diabetes mellitus among a general Japanese population: a cross-sectional study.
Article in SpringerPlus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Association ofWorld journal of clinical pediatrics · 2026Article
- National prevention programs and their effects on gastric cancer Incidence and mortality in East Asian countries.Cancer biology & medicine · 2025Article
- Impact of anti-peptic ulcer disease medications on type 2 diabetes mellitus risk in patients with PUD: a population-based retrospective cohort study.Therapeutic advances in endocrinology and metabolism · 2025Article
- Type 2 Diabetes Mellitus andLife (Basel, Switzerland) · 2024Article
- Metabolic syndrome and associated factors amongFrontiers in endocrinology · 2024Article
- Alcohol intake and stomach cancer risk in Japan: A pooled analysis of six cohort studies.Cancer science · 2022Article
- Factors associated with gastro-duodenal ulcer in compensated type 2 diabetic patients: a Romanian single-center study.Archives of medical science : AMS · 2022Article
- Alcohol Consumption and Risk of Gastric Cancer: The Japan Collaborative Cohort Study.Journal of epidemiology · 2021Article
- Seroprevalence ofJGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Association Between Second-hand Smoke Exposure and Depressive Symptoms Among Japanese Adults: A Cross-sectional Study.Journal of epidemiology · 2020Article
- Association between plasma levels of homocysteine, folate, and vitamin BScientific reports · 2020Article
- Association between Helicobacter pylori infection, eradication and diabetes mellitus.Journal of diabetes investigation · 2019Article
- Helicobacter pylori eradication improves glycemic control in type 2 diabetes patients with asymptomatic active Helicobacter pylori infection.Journal of diabetes investigation · 2019Article
- Association ofExperimental and therapeutic medicine · 2019Article
- Article
- The association between self-rated health and high-sensitivity C-reactive protein level: a cross-sectional and 5-year longitudinal study.BMC public health · 2018Article
- Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan: a cross-sectional study.Medicine · 2018Article
- Helicobacter pylori infection, gestational diabetes mellitus and insulin resistance among pregnant Sudanese women.BMC research notes · 2018Article
- Review
- Associations of Helicobacter pylori infection and peptic disease with diabetic mellitus: Results from a large population-based study.PloS one · 2017Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several case-control studies have reported that patients with diabetes mellitus (DM) had a higher prevalence of Helicobacter pylori infection than those without DM, but these findings remain equivocal. Additionally, there are few studies examining associations between East Asian CagA-positive H. pylori and DM. This cross-sectional study aimed to investigate whether H. pylori infection was a possible risk factor for DM in a general Japanese population. The study included 5165 subjects (1467 men, 3698 women) aged 35-69 years from the Daiko Study, part of the Japan Multi-Institutional Collaborative Cohort Study. A urinary anti-H. pylori antibody was used to detect H. pylori infection. The medical history of physician-diagnosed DM was confirmed by self-administered questionnaire. The odds ratios (ORs) and their 95 % confidence intervals (CIs) for DM (current and former) were calculated using unconditional logistic regression analysis, adjusting for age, sex, educational status, alcohol use, smoking status, body mass index, energy intake, and physical activity. The prevalence of DM was 4.6 % (95 % CI 3.7-5.6 %) among 1878 participants with H. pylori infection and 3.2 % (2.6-3.8 %) among 3287 without the infection (p = 0.009). The crude, age-adjusted, and multivariate-adjusted ORs for DM in those with the infection relative to those without were 1.47 (95 % CI 1.10-1.97), 1.02 (0.76-1.38), and 0.97 (0.71-1.32), respectively. We found a significantly higher DM prevalence among those with H. pylori infection than among those without. However, almost all the difference in prevalence could be explained by the older age of those infected. Our findings did not support an association between H. pylori infection and DM.
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