ArticleMateria socio-medica2015
Clinical Presentation and the Outcome of Therapy in a Cohort of Patients with Methadone Toxicity in Iran.
Article in Materia socio-medica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- The clinico-epidemiological, diagnostic, and therapeutic aspects of methadone poisoning: a registry-based clinical study.Annals of medicine and surgery (2012) · 2024Article
- Serotonin therapies for opioid-induced disordered swallow and respiratory depression.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Evaluation of morphine, methadone, digoxin, and dronabinol poisoning during the years 2017 to 2019 in Ilam, Iran.Caspian journal of internal medicine · 2023Article
- Outcomes associated with hospital admissions for accidental opioid overdose in British Columbia: a retrospective cohort study.BMJ open · 2019Article
- Histopathological study of liver tissue due to methadone consumption and its effect on liver enzymes and inflammatory indices in rat.Drug design, development and therapy · 2018Article
- Nephrotoxicity of methadone: a systematic review.SpringerPlus · 2016Review
- Common Opioids Involved in Drug Poisoning Presenting to the Emergency Department: A Cross-sectional Study.Journal of research in pharmacy practiceArticle
- Predictive Factors of Treatment Outcomes for Hospital Care in Children with Acute Methadone Poisoning.Journal of research in pharmacy practiceArticle
- Prevalence of pulmonary edema among the deceased cases with acute Methadone poisoning: A report from Iran.Journal of research in pharmacy practiceArticle
- The Safety and Effectiveness of Pharmacotherapy for Opioid-Overdose Induced Aspiration Pneumonia in a Referral Poisoning Management University Hospital in Iran.Journal of research in pharmacy practiceArticle
- Cardiovascular Complications Following Acute Methadone Poisoning in Patients with and Without a History of Long-term Methadone Use.Journal of research in pharmacy practiceArticle
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
backgroundAgonist maintenance therapy with methadone is amongst the preferred remedies for treating opioid dependence and is increasingly supported by the regional governments in this part of the world. In this study we have investigated the clinical manifestations and factors affecting the outcome of therapy in patients with methadone poisoning in a Middle-Eastern (Iranian) referral tertiary care University hospital.
methodsIn this prospective and descriptive-analytic study which was done in a tertiary care and referral University hospital in Iran (2012-2013) all of the admitted patients with a clear and reliable history of methadone poisoning (n=433) were included and demographic data, Clinical status on admission including Glasgow Coma Scale (GCS) score, time elapsed from ingestion to hospital admission, average dose of naloxone used, any history of psychiatric disorder, type of toxic exposure, co ingestion of other medication, hospitalization time and the outcome were recorded and statistically analyzed.
resultsThe average length of hospital stay was 33 ± 26 hours. 80.1% of patients had ingested methadone alone, and 90.3% survived. Complications were pulmonary edema (7%), aspiration pneumonia (1.4%), generalized tonic colonic seizure (0.9%), and renal failure (0.5%). GCS, systolic blood pressure and respiratory rate were lower in fatal cases and GCS had prognostic value for the outcome of therapy in methadone intoxicated patients. Patients with higher GCS on admission had better outcome [OR =0.47 (95% CI: 0.38-0.580); P value< 0.0001].
conclusionAdmission time GCS score maybe considered as an important predictor for the outcome of therapy in methadone poisoning.
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