ArticleIndian journal of microbiology2015
Identification of Recombination and Positively Selected Genes in Brucella.
Article in Indian journal of microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
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- Genomic insights intoMicrobiology spectrum · 2025Article
- Unraveling the impact of genome assembly on bacterial typing: a one health perspective.BMC genomics · 2024Article
- OrthoPhyl-streamlining large-scale, orthology-based phylogenomic studies of bacteria at broad evolutionary scales.G3 (Bethesda, Md.) · 2024Article
- Genome Sequencing and Comparative Genomics of Indian Isolates ofFrontiers in microbiology · 2021Article
- Interplay of Various Evolutionary Modes in Genome Diversification and Adaptive Evolution of the FamilyFrontiers in microbiology · 2021Article
- Development of T3SS Mutants (Indian journal of microbiology · 2018Article
- Identification of Cross-Protective Potential Antigens against PathogenicJournal of immunology research · 2018Article
- Whole-Genome Sequencing of Bacterial Pathogens: the Future of Nosocomial Outbreak Analysis.Clinical microbiology reviews · 2017Review
- Enterobacterial Repetitive Intergenic Consensus Polymerase Chain Reaction (ERIC-PCR) Genotyping ofIranian journal of pathology · 2017Article
- Genome-Wide Analyses Reveal Genes Subject to Positive Selection inFrontiers in microbiology · 2017Article
- Respiratory Tularemia:The open microbiology journal · 2016Article
- Microarray long oligo probe designing for Escherichia coli: an in-silico DNA marker extraction.Central European journal of urology · 2016Article
- Identification of Recombination and Positively Selected Genes in Brucella.Indian journal of microbiology · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brucella is a facultative intracellular bacterium belongs to the class alpha proteobacteria. It causes zoonotic disease brucellosis to wide range of animals. Brucella species are highly conserved in nucleotide level. Here, we employed a comparative genomics approach to examine the role of homologous recombination and positive selection in the evolution of Brucella. For the analysis, we have selected 19 complete genomes from 8 species of Brucella. Among the 1599 core genome predicted, 24 genes were showing signals of recombination but no significant breakpoint was found. The analysis revealed that recombination events are less frequent and the impact of recombination occurred is negligible on the evolution of Brucella. This leads to the view that Brucella is clonally evolved. On other hand, 56 genes (3.5 % of core genome) were showing signals of positive selection. Results suggest that natural selection plays an important role in the evolution of Brucella. Some of the genes that are responsible for the pathogenesis of Brucella were found positively selected, presumably due to their role in avoidance of the host immune system.
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