ArticleMolecular biology of the cell2015
Analyzing the dynamics of cell cycle processes from fixed samples through ergodic principles.
Article in Molecular biology of the cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Combining lineage correlations and a small molecule inhibitor to detect circadian control of the cell cycle.iScience · 2025Article
- Short cell cycle duration is a phenotype of human epidermal stem cells.Stem cell research & therapy · 2024Article
- Whole cell reconstructions of Leishmania mexicana through the cell cycle.PLoS pathogens · 2024Article
- Basic Methods of Cell Cycle Analysis.International journal of molecular sciences · 2023Review
- An Analysis of Transcriptomic Burden Identifies Biological Progression Roadmaps for Hematological Malignancies and Solid Tumors.Biomedicines · 2022Article
- Reconstructing data-driven governing equations for cell phenotypic transitions: integration of data science and systems biology.Physical biology · 2022Review
- The palette of techniques for cell cycle analysis.FEBS letters · 2020Review
- ImageJ for Partially and Fully Automated Analysis of Trypanosome Micrographs.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Non-equivalence in old- and new-flagellum daughter cells of a proliferative division in Trypanosoma brucei.Molecular microbiology · 2019Article
- Glycogen synthase kinase 3β inhibition enhances Notch1 recycling.Molecular biology of the cell · 2018Article
- Let's get fISSical: fast in silico synchronization as a new tool for cell division cycle analysis.Parasitology · 2018Review
- Making sense of snapshot data: ergodic principle for clonal cell populations.Journal of the Royal Society, Interface · 2017Article
- Article
- Shape, form, function andOpen biology · 2017Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
Abstract
Tools to analyze cyclical cellular processes, particularly the cell cycle, are of broad value for cell biology. Cell cycle synchronization and live-cell time-lapse observation are widely used to analyze these processes but are not available for many systems. Simple mathematical methods built on the ergodic principle are a well-established, widely applicable, and powerful alternative analysis approach, although they are less widely used. These methods extract data about the dynamics of a cyclical process from a single time-point "snapshot" of a population of cells progressing through the cycle asynchronously. Here, I demonstrate application of these simple mathematical methods to analysis of basic cyclical processes--cycles including a division event, cell populations undergoing unicellular aging, and cell cycles with multiple fission (schizogony)--as well as recent advances that allow detailed mapping of the cell cycle from continuously changing properties of the cell such as size and DNA content. This includes examples using existing data from mammalian, yeast, and unicellular eukaryotic parasite cell biology. Through the ongoing advances in high-throughput cell analysis by light microscopy, electron microscopy, and flow cytometry, these mathematical methods are becoming ever more important and are a powerful complementary method to traditional synchronization and time-lapse cell cycle analysis methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.