ReviewDevelopment, growth & differentiation2016
Timing by rhythms: Daily clocks and developmental rulers.
Review in Development, growth & differentiation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Modes of Notch signalling in development and disease.Nature reviews. Molecular cell biology · 2025Review
- Information Theory as an Experimental Tool for Integrating Disparate Biophysical Signaling Modules.International journal of molecular sciences · 2022Article
- Scaling of internal organs during Drosophila embryonic development.Biophysical journal · 2021Article
- NaScience advances · 2021Article
- From local resynchronization to global pattern recovery in the zebrafish segmentation clock.eLife · 2021Article
- An auxin-regulable oscillatory circuit drives the root clock inScience advances · 2021Article
- Shaping Waves of Bone Morphogenetic Protein Inhibition During Vascular Growth.Circulation research · 2020Article
- Temporal Coordination of Collective Migration and Lumen Formation by Antagonism between Two Nuclear Receptors.iScience · 2020Article
- Rhythmicity and waves in the cortex of single cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Delta-Notch signalling in segmentation.Arthropod structure & development · 2017Review
- Evaluating the Autonomy of theFrontiers in cellular neuroscience · 2017Article
- Is the Epididymis a Series of Organs Placed Side By Side?Biology of reproduction · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Biological rhythms are widespread, allowing organisms to temporally organize their behavior and metabolism in advantageous ways. Such proper timing of molecular and cellular events is critical to their development and health. This is best understood in the case of the circadian clock that orchestrates the daily sleep/wake cycle of organisms. Temporal rhythms can also be used for spatial organization, if information from an oscillating system can be recorded within the tissue in a manner that leaves a permanent periodic pattern. One example of this is the "segmentation clock" used by the vertebrate embryo to rhythmically and sequentially subdivide its elongating body axis. The segmentation clock moves with the elongation of the embryo, such that its period sets the segment length as the tissue grows outward. Although the study of this system is still relatively young compared to the circadian clock, outlines of molecular, cellular, and tissue-level regulatory mechanisms of timing have emerged. The question remains, however, is it truly a clock? Here we seek to introduce the segmentation clock to a wider audience of chronobiologists, focusing on the role and control of timing in the system. We compare and contrast the segmentation clock with the circadian clock, and propose that the segmentation clock is actually an oscillatory ruler, with a primary function to measure embryonic space.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.