Evidence map›Paper›PMID 26542778›Full record

ArticleHuman genomics2015

HDAC3 role in medication consumption in medication overuse headache patients: a pilot study.

Claudia Pisanu, Stefano Caproni, Donatella Congiu, Letizia M Cupini, Alessio Squassina, George P Patrinos, Ilenia Corbelli, Paolo Calabresi, Maria Del Zompo, Paola Sarchielli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Claudia PisanuSection of Neurosciences and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, SP8 Km. 0,700, 09042, Monserrato (CA), Italy.
Stefano CaproniNeurologic Clinic, University of Perugia, Perugia, Italy.
Donatella CongiuSection of Neurosciences and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, SP8 Km. 0,700, 09042, Monserrato (CA), Italy.
Letizia M CupiniHeadache and Cerebrovascular Diseases Center, Ospedale S. Eugenio, Rome, Italy.
Alessio SquassinaSection of Neurosciences and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, SP8 Km. 0,700, 09042, Monserrato (CA), Italy.
George P PatrinosDepartment of Pharmacy, University of Patras, School of Health Sciences, Patras, Greece. gpatrinos@upatras.gr.
Ilenia CorbelliNeurologic Clinic, University of Perugia, Perugia, Italy.
Paolo CalabresiNeurologic Clinic, University of Perugia, Perugia, Italy.
Maria Del ZompoSection of Neurosciences and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, SP8 Km. 0,700, 09042, Monserrato (CA), Italy. delzompo@unica.it.
Paola SarchielliNeurologic Clinic, University of Perugia, Perugia, Italy.
University of Perugia · ITUniversity of Cagliari · ITSt. Eugenio Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMedication overuse headache (MOH) is a common and debilitating disorder characterized by generation, perpetuation, and persistence of intense chronic migraine, caused by overuse of analgesics, triptans, or other acute headache compounds. It has been suggested that MOH could share some pathogenetic mechanisms with other kinds of drug addiction. In this regard, histone deacetylases 3 (HDAC3) seems to have a role in the memory processes involved in extinction of drug-seeking behavior in animal models. HDAC3 is inhibited by sodium valproate, a drug with proven efficacy in MOH. Recent evidence suggests an involvement of genetic factors in predisposition to medication overuse.

resultsIn this association study, we sequenced all exons, intron/exon junctions, and 3'-5'UTR regions of HDAC3 in 23 MOH patients to investigate its role in medication overuse. Associations between genotypes with continuous and dichotomous clinical characteristics were tested by multivariate analysis and Fisher's exact test, respectively. Sequencing of HDAC3 revealed six single-nucleotide polymorphisms. The G allele of rs2530223 was significantly associated with the number of acute medications/month used and with the number of days/month in which medications were used (p = 0.006 and p = 0.007, respectively), but neither with headache frequency or intensity. None of the single-nucleotide polymorphisms (SNPs) was associated with clinical characteristics or response to sodium valproate.

conclusionsHDAC3 could be implicated in excessive medication consumption in MOH patients. Our preliminary findings provide support for the need of further investigation on larger independent samples to confirm and extend the role of HDAC3 in medication overuse headache.

Indexed as

Genetic Association StudiesAdultFemaleHeadache Disorders, SecondaryHigh-Throughput Nucleotide SequencingHistone Deacetylase 3Histone DeacetylasesHumansMaleMiddle AgedMigraine DisordersPilot ProjectsPolymorphism, Single NucleotidePrescription Drug OveruseValproic AcidHistone Deacetylase 3Histone DeacetylasesValproic Acid

Identifiers

PMID26542778
PMCPMC4635554
OpenAlexW1953025992

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.