ReviewReviews in endocrine & metabolic disorders2015
The role of prolactin in andrology: what is new?
Review in Reviews in endocrine & metabolic disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 84 citations in OpenAlex.
- Endocrine-metabolic crosstalk in erectile dysfunction: mechanistic insights and therapeutic implications.International journal of impotence research · 2026Review
- Sexual Dysfunctions Associated with Proton Pump Inhibitors: Insights from VigiBase, the World Health Organization Pharmacovigilance Database.Drug safety · 2026Article
- Sleep-related painful erection, erectile dysfunction and psychological distress.Frontiers in psychiatry · 2026Article
- MicroRNAs in seminal plasma are able to discern infertile men at increased risk of developing testicular cancer.Molecular oncology · 2025Article
- Hormonal and Glycemic Responses During and After Constant- and Alternating-Intensity Exercise.Journal of clinical medicine · 2025Article
- Idiopathic hyperprolactinemia-associated hypogonadism in men presenting with normal testosterone levels.PloS one · 2025Article
- Acquired hypoprolactinemia in men, possible phenotype.Reviews in endocrine & metabolic disorders · 2024Review
- Prolactin deficiency in the context of other pituitary hormone abnormalities : Special issue: hypoprolactinemia: a neglected endocrine disorder.Reviews in endocrine & metabolic disorders · 2024Review
- Hypoprolactinemia. Does it matter? Redefining the hypopituitarism and return from a mumpsimus : "Absence of proof is not the proof of absence".Reviews in endocrine & metabolic disorders · 2024Review
- Diagnosis of hypoprolactinemia.Reviews in endocrine & metabolic disorders · 2024Review
- Drug induced hypoprolactinemia.Reviews in endocrine & metabolic disorders · 2024Review
- The molecular basis of hypoprolactinaemia.Reviews in endocrine & metabolic disorders · 2024Review
- What do we know about abnormally low prolactin levels in polycystic ovary syndrome? A narrative review.Reviews in endocrine & metabolic disorders · 2024Review
- Association between sex hormones and erectile dysfunction in men without hypoandrogenism.Scientific reports · 2024Article
- Cognition and psychological wellbeing in hypopituitary patients.Reviews in endocrine & metabolic disorders · 2024Review
- The diagnosis and prevalence of hypoprolactinemia in patients with panhypopituitarism and the effects on depression and sexual functions.Pituitary · 2024Article
- Prolactin and spermatogenesis: new lights on the interplay between prolactin and sperm parameters.Endocrine · 2023Article
- The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction.Journal of endocrinological investigation · 2023Article
- Mechanisms of Lactation-induced Infertility in Female Mice.Endocrinology · 2023Article
- Erectile dysfunction as a marker of endocrine and glycemic disorders.Journal of endocrinological investigation · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolactin (PRL) has been long deemed as a hormone involved only in female reproduction. However, PRL is a surprising hormone and, since its identification in the 1970s, its attributed functions have greatly increased. However, its specific role in male health is still widely unknown. Recently, low PRL has been associated with reduced ejaculate and seminal vesicle volume in infertile subjects. In addition, in men consulting for sexual dysfunction, hypoprolactinemia has been associated with erectile dysfunction and premature ejaculation, findings further confirmed in the general European population and infertile men. Several metabolic derangements, recapitulating metabolic syndrome, have also been associated with low PRL both in men with sexual dysfunction and from the general European population. In men with sexual dysfunction, followed-up for more than 4 years, low PRL was identified as an independent predictor of the incidence of major adverse cardiovascular events. Finally, an association with anxiety or depressive symptoms has been found in men with sexual dysfunction and from the general European population. While a direct role for impaired PRL function in the pathogenesis of these reproductive, sexual, metabolic and psychological disorders is conceivable, the possibility that low PRL is a mirror of an increased dopaminergic or a decreased serotonergic tone cannot be ruled-out. Hyperactivity of the dopaminergic system can explain only a few of the aforementioned findings, whereas a hypo-serotonergic tone fits well with the clinical features associated with low PRL, and there is significant evidence supporting the hypothesis that PRL could be a mirror of serotonin in the brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.