ArticleAnnals of surgical oncology2016
Tumor Characteristics and Survival Outcome of Endometrial Cancer Arising in Adenomyosis: An Exploratory Analysis.
Article in Annals of surgical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of adenomyosis on the prognosis of patients with endometrial cancer.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022Pooled it
- The Impact of Adenomyosis on Pregnancy.Biomedicines · 2024Review
- Adenomyosis and Its Possible Malignancy: A Review of the Literature.Diagnostics (Basel, Switzerland) · 2023Review
- Endometrioid adenocarcinoma arising in adenomyosis in a patient with pelvic organ prolapse-case report.BMC women's health · 2023Article
- Review
- Review
- Clinicopathological Characteristics and Prognosis in Endometrial Cancer With Bone Metastasis: A SEER-Based Study of 584 Women.Frontiers in oncology · 2021Article
- The clinicopathological characteristics and survival outcomes of endometrial carcinoma coexisting with or arising in adenomyosis: A pilot study.Scientific reports · 2020Article
- Co-existence of leiomyomas, adenomyosis and endometriosis in women with endometrial cancer.Scientific reports · 2020Article
- Association of benign gynaecological diseases and risk of endometrial and ovarian cancers.Journal of Cancer · 2020Article
- Treatment and outcome of placenta percreta: Primary cesarean hysterectomy versus conservative management.European journal of obstetrics, gynecology, and reproductive biology · 2020Article
- LncRNA miR143HG Up-Regulates p53 In Endometrial Carcinoma By Sponging miR-125a.Cancer management and research · 2019Article
- Correlation between Adenomyosis and Endometrial cancer: 6-year experience of a single center.Facts, views & vision in ObGyn · 2018Article
- Significance of abnormal peritoneal cytology on survival of women with stage I-II endometrioid endometrial cancer.Gynecologic oncology · 2018Observational
- Women with adenomyosis are at higher risks of endometrial and thyroid cancers: A population-based historical cohort study.PloS one · 2018Article
- Coexistence of adenomyosis uteri and endometrial cancer is associated with an improved prognosis compared with endometrial cancer only.Oncology letters · 2017Article
- Endometrial cancer arising in adenomyosis versus endometrial cancer coexisting with adenomyosis: are these two different entities?Archives of gynecology and obstetrics · 2017Article
- Endometrioid adenocarcinoma originating simultaneously from endometrium, sites of adenomyosis and ovarian endometriosis: A case report and review of our cancer database.International journal of surgery case reports · 2017Article
- Association of Low-Dose Aspirin and Survival of Women With Endometrial Cancer.Obstetrics and gynecology · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundEndometrial cancer arising in adenomyosis (EC-AIA) is a rare entity of endometrial cancer, and its clinical significance has not been well studied. This study aimed to examine the tumor characteristics and survival outcomes of EC-AIA.
methodsAn exploratory analysis was performed to compare EC-AIA and historical control cases. For this study, EC-AIA cases were identified via a systematic literature search using PubMed/MEDLINE with entry keywords "endometrial cancer OR uterine cancer" AND "adenomyosis" (n = 46). The control group comprised consecutive non-EC-AIA cases from four institutions that had hysterectomy-based surgical staging (n = 1294). Patient demographics, pathology results, and survival outcomes were evaluated between the two groups.
resultsThe EC-AIA group was significantly older than the control group (58.9 vs. 55.3 years; P = 0.032). In terms of tumor characteristics, 56.5% of the EC-AIA cases showed tumor within the myometrium without endometrial extension, and the EC-AIA group was significantly more likely to have tumors with more than 50% myometrial invasion (51.6 vs. 26.6%; P = 0.002) and serous/clear cell histology (22.2 vs. 8.2%, P = 0.002) while less likely to express estrogen receptor (14.3 vs. 84.6%; P < 0.001). Grade and stage distributions were similar (P > 0.05). In the univariate analysis, the EC-AIA group had a significantly poorer disease-free survival than the control group (5-year rate: 71.4 vs. 80.6%; P = 0.014). In the multivariate analysis, with control for age, ethnicity, histology, grade, and stage, EA-CIC remained an independent prognostic factor for decreased disease-free survival (adjusted hazard ratio, 3.07; 95% confidence interval 1.55-6.08; P = 0.001).
conclusionsThe study suggested that endometrial cancer arising in adenomyosis may be an aggressive variant of endometrial cancer.
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