ArticleScientific reports2015
Neutralization of Japanese Encephalitis Virus by heme-induced broadly reactive human monoclonal antibody.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Oxidized hemoglobin triggers polyreactivity and autoreactivity of human IgG via transfer of heme.Communications biology · 2023Article
- Japanese encephalitis virus persists in the human reproductive epithelium and porcine reproductive tissues.PLoS neglected tropical diseases · 2022Article
- Antigen binding by conformational selection in near-germline antibodies.The Journal of biological chemistry · 2022Article
- Is hemolysis a novel therapeutic target in COVID-19?Frontiers in immunology · 2022Article
- Is haem the real target of COVID-19?Photodiagnosis and photodynamic therapy · 2021Article
- Linking COVID-19 and Heme-Driven Pathophysiologies: A Combined Computational-Experimental Approach.Biomolecules · 2021Article
- Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities.Communications biology · 2021Article
- Japanese Encephalitis Virus Infected Human Monocyte-Derived Dendritic Cells Activate a Transcriptional Network Leading to an Antiviral Inflammatory Response.Frontiers in immunology · 2021Article
- Rarely Recognized Antibody Diversification in Covid-19 Evolution to Counteract Advanced SARS-CoV-2 Evasion Strategies, and Implications for Prophylactic Treatment.Frontiers in physiology · 2021Article
- Linear and Continuous Flavivirus Epitopes From Naturally Infected Humans.Frontiers in cellular and infection microbiology · 2021Review
- Article
- Breaking the law: unconventional strategies for antibody diversification.Nature reviews. Immunology · 2019Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Geographical expansion and re-emerging new genotypes of the Japanese encephalitis virus (JEV) require the development of novel therapeutic approaches. Here, we studied a non-conventional approach for antibody therapy and show that, upon exposure to heme, a fraction of natural human immunoglobulins acquires high-affinity reactivity with the antigenic domain-III of JEV E glycoprotein. These JEV-reactive antibodies exhibited neutralizing activity against recently dominant JEV genotypes. This study opens new therapeutic options for Japanese encephalitis.
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