Evidence map›Paper›PMID 26542234›Full record

ArticleAJNR. American journal of neuroradiology2016

Structural Brain Alterations in Community Dwelling Individuals with Chronic Joint Pain.

M de Kruijf, D Bos, F J P M Huygen, W J Niessen, H Tiemeier, A Hofman, A G Uitterlinden, M W Vernooij, M A Ikram, J B J van Meurs

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05986513 (Investigating Brain Abnormalities in People With Knee Osteoarthritis Using MRI), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05986513 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Investigating Brain Abnormalities in People With Knee Osteoarthritis Using MRI: a Nociplastic Pain Mechanism Based Assessment

TypeinterventionalSponsorToronto Rehabilitation InstituteRan2023 to 2025Enrolled66ConditionsChronic Pain, Central Sensitisation, Knee OsteoarthritisArmsCold Pressor Gel Test
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

M de KruijfFrom the Departments of Internal Medicine (M.d.K., A.G.U., J.B.J.v.M.) Anaesthesiology (M.d.K., F.J.P.M.H.).
D BosRadiology (D.B., W.J.N., M.W.V., M.A.I.) Epidemiology (D.B., H.T., A.H., A.G.U., M.W.V., M.A.I.).
F J P M HuygenAnaesthesiology (M.d.K., F.J.P.M.H.).
W J NiessenRadiology (D.B., W.J.N., M.W.V., M.A.I.) Medical Informatics (W.J.N.) Faculty of Applied Sciences (W.J.N.), Delft University of Technology, Delft, the Netherlands.ORCID http://orcid.org/0000-0002-5822-1995
H TiemeierEpidemiology (D.B., H.T., A.H., A.G.U., M.W.V., M.A.I.).
A HofmanEpidemiology (D.B., H.T., A.H., A.G.U., M.W.V., M.A.I.).ORCID http://orcid.org/0000-0002-9865-121X
A G UitterlindenFrom the Departments of Internal Medicine (M.d.K., A.G.U., J.B.J.v.M.) Epidemiology (D.B., H.T., A.H., A.G.U., M.W.V., M.A.I.).
M W VernooijRadiology (D.B., W.J.N., M.W.V., M.A.I.) Epidemiology (D.B., H.T., A.H., A.G.U., M.W.V., M.A.I.).ORCID http://orcid.org/0000-0003-4658-2176
M A IkramRadiology (D.B., W.J.N., M.W.V., M.A.I.) Epidemiology (D.B., H.T., A.H., A.G.U., M.W.V., M.A.I.) Neurology (M.A.I.), Erasmus MC, University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
J B J van MeursFrom the Departments of Internal Medicine (M.d.K., A.G.U., J.B.J.v.M.) j.vanmeurs@erasmusmc.nl.
MACOM (United States) · USDelft University of Technology · NLErasmus MC · NLErasmus University Rotterdam · NLEuropean Society of Anaesthesiology · BEJisc · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCentral sensitization in chronic pain involves structural brain changes that influence vulnerability to pain. Identifying brain regions involved in pain processing and sensitization can provide more insight into chronic pain. This study examines structural brain changes in chronic pain and experimental pain in a large population-based study. MATERIALS AND

methodsFor 3892 participants in the Rotterdam study, global and regional MR imaging brain volumes were automatically segmented and quantified. Chronic joint pain was defined as pain for more than half of all days during the past 6 weeks. Heat pain thresholds were measured in a subset of 1538 individuals. The association between the presence of chronic joint pain and global and lobar brain volumes was studied. Subsequently, literature was reviewed and the association of chronic pain and heat pain thresholds with 11 brain regions associated with musculoskeletal pain in previous publications was studied.

resultsTotal gray matter volume was smaller in women with chronic pain (β = -0.066, P = .016). This effect was primarily driven by lower gray matter volume in the temporal lobe (β = 0.086, P = .005), the frontal lobe (β = -0.060, P = .039), and the hippocampus (β = -0.099, P = .002). In addition, we observed that a lower heat pain threshold was associated with smaller volumes of the hippocampus (β = 0.017, P = .048), the thalamus (β = 0.018, P = .009), and the anterior cingulate cortex (β = -0.016, P = .037). In men, no significant associations were observed.

conclusionsThe primary identified brain areas, the temporal and frontal lobes and the hippocampus, indicated involvement of emotional processing. The volumetric differences found indicated a sex-specific neuroplasticity in chronic pain. These results emphasized sex-specific and multidisciplinary pain treatment.

Indexed as

AdultArthralgiaBrainCentral Nervous System SensitizationChronic PainFemaleHumansIndependent LivingMagnetic Resonance ImagingMaleSex CharacteristicsYoung Adult

Identifiers

PMID26542234
PMCPMC7960137
OpenAlexW2115561183

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.