Evidence map›Paper›PMID 26542222›Full record

ArticleTuberculosis (Edinburgh, Scotland)2015

Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak.

Joseph W Saelens, Dalia Lau-Bonilla, Anneliese Moller, Narda Medina, Brenda Guzmán, Maylena Calderón, Raúl Herrera, Dana M Sisk, Ana M Xet-Mull, Jason E Stout and 3 more

Abstract read
In one paragraph

Article in Tuberculosis (Edinburgh, Scotland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Circulation ofPathogens and global health · 2019
    Review
  5. Review
  6. Annotated Genome Sequences of 16 Lineage 4Genome announcements · 2018
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joseph W SaelensDepartment of Molecular Genetics and Microbiology and Center for Host-Microbial Interactions, Duke University Medical Center, Durham, NC, USA.
Dalia Lau-BonillaAsociación de Salud Integral, Guatemala City, Guatemala.
Anneliese MollerAsociación de Salud Integral, Guatemala City, Guatemala.
Narda MedinaAsociación de Salud Integral, Guatemala City, Guatemala.
Brenda GuzmánAsociación de Salud Integral, Guatemala City, Guatemala.
Maylena CalderónAsociación de Salud Integral, Guatemala City, Guatemala.
Raúl HerreraAsociación de Salud Integral, Guatemala City, Guatemala.
Dana M SiskDepartment of Molecular Genetics and Microbiology and Center for Host-Microbial Interactions, Duke University Medical Center, Durham, NC, USA.
Ana M Xet-MullDepartment of Molecular Genetics and Microbiology and Center for Host-Microbial Interactions, Duke University Medical Center, Durham, NC, USA.
Jason E StoutDepartment of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, NC, USA.
Eduardo ArathoonHospital General San Juan de Dios, Guatemala City, Guatemala; Clínica Familiar Luis Ángel García, Guatemala City, Guatemala.
Blanca SamayoaAsociación de Salud Integral, Guatemala City, Guatemala; Facultad de Ciencias Químicas y Farmacia, Universidad de San Carlos de Guatemala, Guatemala City, Guatemala. Electronic address: investigacion@asi.org.gt.
David M TobinDepartment of Molecular Genetics and Microbiology and Center for Host-Microbial Interactions, Duke University Medical Center, Durham, NC, USA. Electronic address: david.tobin@duke.edu.

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
The Genetic Basis of Bone Disease in Mycobacterial InfectionR21AI111067 · NIAID · DUKE UNIVERSITY · PI LEE, SUNHEE, STOUT, JASON E · 2015 to 2016
$434k
NIAID NIH HHS P30 AI064518NIAID NIH HHS R21 AI111067
6 · The paper itself

Abstract

Limited data are available regarding the molecular epidemiology of Mycobacterium tuberculosis (Mtb) strains circulating in Guatemala. Beijing-lineage Mtb strains have gained prevalence worldwide and are associated with increased virulence and drug resistance, but there have been only a few cases reported in Central America. Here we report the first whole genome sequencing of Central American Beijing-lineage strains of Mtb. We find that multiple Beijing-lineage strains, derived from independent founding events, are currently circulating in Guatemala, but overall still represent a relatively small proportion of disease burden. Finally, we identify a specific Beijing-lineage outbreak centered on a poor neighborhood in Guatemala City.

Indexed as

Disease OutbreaksGenome, BacterialUrban HealthChinaDatabases, GeneticDNA, BacterialGenotypeGuatemalaHumansMolecular EpidemiologyMycobacterium tuberculosisPhenotypePhylogenyPolymorphism, Single NucleotidePovertyPredictive Value of TestsDNA, BacterialBeijing strainsCentral AmericaGuatemalaMolecular epidemiologyTuberculosisWhole genome sequencing

Identifiers

PMID26542222
PMCPMC4672993

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.