ArticleScientific reports2015
Lignosus rhinocerotis (Cooke) Ryvarden mimics the neuritogenic activity of nerve growth factor via MEK/ERK1/2 signaling pathway in PC-12 cells.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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9 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Application of Medicinal Mushrooms for the Treatment of Peripheral Nerve Injury: A Systematic Review.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Review
- Protective Effect of Fucoidan against MPPMarine drugs · 2020Article
- Human Embryonic Stem Cell-Derived Neural Lineages asBioMed research international · 2019Article
- Effect of lower chlorinated hydroxylated-polychlorobiphenyls on development of PC12 cells.Environmental science and pollution research international · 2018Article
- 6-shogaol, a neuroactive compound of ginger (jahe gajah) induced neuritogenic activity via NGF responsive pathways in PC-12 cells.BMC complementary and alternative medicine · 2017Article
- The potential neuritogenic activity of aqueous extracts fromFood science and biotechnology · 2017Article
- A Status Review of the Bioactive Activities of Tiger Milk MushroomFrontiers in pharmacology · 2017Review
- Signaling pathways involved in HSP32 induction by hyperbaric oxygen in rat spinal neurons.Redox biology · 2016Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The traditional application of the sclerotium of Lignosus rhinocerotis (tiger's milk mushroom) by the indigenous folks as tonic and remedy to treat a variety of ailments has been documented in Malaysia. Indigenous communities claimed to have consumed the decoction to boost their alertness during hunting. Mental alertness is believed to be related to neuronal health and neuroactivity. In the present study, the cell viability and neuritogenic effects of L. rhinocerotis sclerotium hot aqueous and ethanolic extracts, and crude polysaccharides on rat pheochromocytoma (PC-12) cells were studied. Interestingly, the hot aqueous extract exhibited neuritogenic activity comparable to NGF in PC-12 cells. However, the extracts and crude polysaccharides stimulated neuritogenesis without stimulating the production of NGF in PC-12 cells. The involvements of the TrkA receptor and MEK/ERK1/2 pathway in hot aqueous extract-stimulated neuritogenesis were examined by Trk (K252a) and MEK/ERK1/2 (U0126 and PD98059) inhibitors. There was no significant difference in protein expression in NGF- and hot aqueous extract-treated cells for both total and phosphorylated p44/42 MAPK. The neuritogenic activity in PC-12 cells stimulated by hot aqueous and ethanolic extracts, and crude polysaccharides of L. rhinocerotis sclerotium mimicking NGF activity via the MEK/ERK1/2 signaling pathway is reported for the first time.
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