SynthesisNature communications2015
Meta-analysis identifies seven susceptibility loci involved in the atopic march.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
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92citing papers in PubMed, 3 pooled it
9.8field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
92 citing papers in PubMed, 3 syntheses or guidelines pooled it, 174 citations in OpenAlex.
- Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis.Nature communications · 2025Pooled it
- Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile.Human molecular genetics · 2022Pooled it
- IL-4 rs2243250 polymorphism associated with susceptibility to allergic rhinitis: a meta-analysis.Bioscience reports · 2021Pooled it
- Differential associations of allergic disease genetic variants with developmental profiles of eczema, wheeze and rhinitis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Identification of two early life eczema and non-eczema phenotypes with high risk for asthma development.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Allergy-specific Phenome-Wide Association Study for Immunogenes in Turkish Children.Scientific reports · 2016Trial
- Genetic variants associated with clinical characteristics and atopies in eosinophilic esophagitis.The journal of allergy and clinical immunology. Global · 2026Article
- Global Prevalence of Asthma in Adults with Atopic Dermatitis and the Atopic Dermatitis-Asthma Association.Pharmaceuticals (Basel, Switzerland) · 2026Review
- IL-13 and calpain-14 suppress the expression of SPINK7 by regulating OVOL1 in eosinophilic esophagitis.JCI insight · 2026Article
- Interactive Effects of Genetic Susceptibility and Early-Life Tobacco Smoke Exposure on the Asthma-Eczema Complex Phenotype in Children: 6-Year Follow-Up Case-Control Study.International journal of molecular sciences · 2025Article
- Retrospective Study of Severe Atopic Disease in Young Children (0-5 Years) Managed with Dupilumab Highlights Significant Comorbidities.Children (Basel, Switzerland) · 2025Article
- Skin-lung axis in the atopic march: The immune link from skin to lungs.Chinese medical journal pulmonary and critical care medicine · 2025Review
- Massively parallel analysis of genotype-dependent enhancer activity among atopic dermatitis genetic risk variants.The Journal of allergy and clinical immunology · 2025Article
- Maternal Folic Acid Supplementation, Perinatal Factors, and Pre-Adolescent Asthma: Findings from the Healthy Growth Study.Nutrients · 2025Article
- GWAS Identifies CACNA2D3 Associated With Asthma and Atopic Dermatitis Multimorbidity in Children.Allergy · 2025Article
- Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity.Immunity, inflammation and disease · 2025Article
- Comparative Real-World Analysis of Baseline Demographic Characteristics and Comorbidities in Atopic Dermatitis Patients Initiating Biologics Versus JAK Inhibitors.Journal of clinical medicine · 2025Article
- Review
- From Pathogenesis to Treatment: Targeting Type-2 Inflammation in Eosinophilic Esophagitis.Biomolecules · 2024Review
- Genetics of chronic respiratory disease.Nature reviews. Genetics · 2024Review
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
73 authors at 20 institutions in 11 countries.
Ingo MarenholzMax-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Jorge Esparza-GordilloMax-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Franz RüschendorfMax-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Anja BauerfeindMax-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
David P StrachanPopulation Health Research Institute, St George's, University of London, London, UK.
Ben D SpycherInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Hansjörg BaurechtDepartment of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Patricia Margaritte-JeanninInserm, UMR-946, F-75010 Paris, France.
Annika SääfInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Marjan KerkhofUniversity of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands.
Markus EgeDr von Hauner Children's Hospital, Ludwig Maximilians University Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.
Svetlana BalticLung Institute of Western Australia, University of Western Australia, Perth, Western Australia, Australia.
Melanie C MathesonCentre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Victoria, Australia.
Jin LiCenter for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Sven MichelDepartment of Pediatric Pneumology and Allergy, University Children`s Hospital Regensburg (KUNO), Regensburg, Germany.ORCID http://orcid.org/0000-0003-3604-3187
Wei Q AngSchool of Women and Infant's Health, University of Western Australia, Perth, Western Australia, Australia.
Wendy McArdleSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Andreas ArnoldClinic and Polyclinic of Dermatology, University Medicine Greifswald, Greifswald, Germany.
Georg HomuthDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
Florence DemenaisInserm, UMR-946, F-75010 Paris, France.ORCID http://orcid.org/0000-0001-8361-0936
Emmanuelle BouzigonInserm, UMR-946, F-75010 Paris, France.
Cilla SöderhällDepartment of Biosciences and Nutrition, and Center for Innovative Medicine (CIMED), Karolinska Institutet, Stockholm, Sweden.
Göran PershagenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Johan C de JongsteDepartment of Pediatrics, Pediatric Chest Center, Erasmus University Medical Center, Rotterdam, The Netherlands.
Dirkje S PostmaDepartment of Pulmonology and GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Charlotte Braun-FahrländerSwiss Tropical and Public Health Institute and the University of Basel, Basel, Switzerland.
Elisabeth HorakDivision of Pediatric Cardiology and Pulmonology, Department of Pediatrics, Innsbruck Medical University, Innsbruck, Austria.
Ludmila M OgorodovaSiberian State Medical University, Tomsk, Russia.
Valery P PuzyrevSiberian State Medical University, Tomsk, Russia.
Elena Yu BraginaResearch Institute of Medical Genetics, Tomsk, Russia.
Thomas J HudsonOntario Institute for Cancer Research, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-1376-4849
Charles MorinCentre de santé et de services sociaux de Chicoutimi, Saguenay, Québec, Canada.
David L DuffyQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-7227-632X
Guy B MarksWoolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Colin F RobertsonDepartment of Respiratory Medicine, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Grant W MontgomeryQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Bill MuskBusselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Philip J ThompsonLung Institute of Western Australia, University of Western Australia, Perth, Western Australia, Australia.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Alan JamesBusselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Patrick SleimanCenter for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Elina ToskalaDepartment of Otolaryngology-Head and Neck Surgery, Temple University, School of Medicine, Philadelphia, Pennsylvania, USA.
Elke RodriguezDepartment of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Regina Fölster-HolstDepartment of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Wolfgang LiebInstitute of Epidemiology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Christian GiegerResearch Unit of Molecular Epidemiology and Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Andrea HeinzmannUniversity Children's Hospital, Albert Ludwigs University, Freiburg, Germany.
Ernst RietschelUniversity Children's Hospital, University of Cologne, Cologne, Germany.
Thomas KeilInstitute of Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany.
Sven CichonInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Craig E PennellSchool of Women and Infant's Health, University of Western Australia, Perth, Western Australia, Australia.
Peter D SlyQueensland Children's Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia.
Carsten O SchmidtInstitute for Community Medicine, Study of Health in Pomerania/KEF, University Medicine Greifswald, Greifswald, Germany.
Anja MatanovicMax-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Valentin SchneiderMax-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Matthias HeinigMax-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Norbert HübnerMax-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Patrick G HoltQueensland Children's Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia.
Susanne LauDepartment of Pediatric Pneumology and Immunology, Charité University Medical Center, Berlin, Germany.
Michael KabeschDepartment of Pediatric Pneumology and Allergy, University Children`s Hospital Regensburg (KUNO), Regensburg, Germany.
Stefan WeidingerDepartment of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Hakon HakonarsonCenter for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Manuel A R FerreiraQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Catherine LapriseUniversité du Québec à Chicoutimi, Saguenay, Québec, Canada.
Maxim B FreidinResearch Institute of Medical Genetics, Tomsk, Russia.
Jon GenuneitInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.ORCID http://orcid.org/0000-0001-5764-1528
Gerard H KoppelmanDepartment of Pediatric Pulmonology and Pediatric Allergology, University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital and GRIAC Research Institute, Groningen, The Netherlands.
Erik MelénInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Marie-Hélène DizierInserm, UMR-946, F-75010 Paris, France.
A John HendersonSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Young Ae LeeMax-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Max Delbrück Center · DEInserm · FRKarolinska Institutet · SEQIMR Berghofer Medical Research Institute · AUThe University of Western Australia · AUUniversity Hospital Schleswig-Holstein · DEChildren's Hospital of Philadelphia · USUniversity Medical Center Groningen · NLChristian-Albrechts-Universität zu Kiel · DEResearch Institute of Medical Genetics of Russian Academy of Medical Sciences · RUSiberian State Medical University · RUSir Charles Gairdner Hospital · AUThe University of Queensland · AUUniversitätsmedizin Greifswald · DEUniversity Hospital Regensburg · DEUniversity of Bonn · DEUniversity of Bristol · GBCentre de Santé et de Services Sociaux de Chicoutimi · CACharité - Universitätsmedizin Berlin · DEErasmus MC · NL
Funding
Medical Research Council G0601361Medical Research Council MC_PC_15018Wellcome Trust 102215
Abstract
Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10(-8)) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10(-9)). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema.
Indexed as
Adaptor Proteins, Vesicular TransportAdolescentAdultAmino Acid Transport Systems, NeutralAsthmaCalcium-Binding ProteinsCarrier ProteinsChildChild, PreschoolDermatitis, AtopicDisease ProgressionDNA-Binding ProteinsFemaleFilaggrin ProteinsGenetic Predisposition to DiseaseGenome-Wide Association StudyAdaptor Proteins, Vesicular TransportAmino Acid Transport Systems, NeutralAP5B1 protein, humanCalcium-Binding ProteinsCarrier ProteinsDNA-Binding ProteinsEFHC1 protein, humanEMSY protein, humanFGFR1 protein, humanFilaggrin ProteinsFLG protein, humanIkaros Transcription FactorIKZF3 protein, humanIL4 protein, humanInterleukin-4KIF3A protein, humanKinesinsLRRC32 protein, humanMembrane ProteinsNeoplasm ProteinsNerve Tissue ProteinsNuclear ProteinsOVOL1 protein, humanReceptor, Fibroblast Growth Factor, Type 1Repressor ProteinsSLC6A15 protein, humanTMTC2 protein, humanTranscription Factors
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