Evidence map›Paper›PMID 26542082›Full record

ArticleNeurorehabilitation and neural repair2016

Vagus Nerve Stimulation During Rehabilitative Training Improves Forelimb Recovery After Chronic Ischemic Stroke in Rats.

Navid Khodaparast, Michael P Kilgard, Reema Casavant, Andrea Ruiz, Iqra Qureshi, Patrick D Ganzer, Robert L Rennaker, Seth A Hays

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurorehabilitation and neural repair, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 88 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04534556 naenrolling by invitationnot on this mapstarted 2021, after this paper: background citation

Wireless Nerve Stimulation Device To Enhance Recovery After Stroke

TypeinterventionalSponsorBaylor Research InstituteRan2021 to 2027Enrolled42ConditionsStroke, Chronic Stroke, Upper Extremity Paresis, Ischemic StrokeArmsActive Vagus Nerve Stimulation, Placebo Vagus Nerve Stimulation
NCT06722677 narecruitingnot on this mapstarted 2024, after this paper: background citation

A Multi-Center, Triple-Blind, Randomized, Sham-Controlled Trial Assessing the Efficacy and Safety of Rehabilitation Paired with Vagus Nerve Stimulation for Upper Extremity Motor Function in Patients with Ischemic Stroke (Repair Study)

TypeinterventionalSponsorBeijing Pins Medical Co., LtdRan2024 to 2025Enrolled99ConditionsIschemic Stroke, Upper Extremity ParesisArmsVNS, Sham VNS, Rehabilitation
3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 3 syntheses or guidelines pooled it, 130 citations in OpenAlex.

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  19. Mapping the role of vagus nerve stimulation in post-stroke arm motor recovery.Journal of neuroengineering and rehabilitation · 2025
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Navid KhodaparastThe University of Texas at Dallas, Richardson, TX 75080-3021, USA.
Michael P KilgardThe University of Texas at Dallas, Richardson, TX 75080-3021, USA.
Reema CasavantMicro Transponder Inc, Dallas, TX 75204, USA.
Andrea RuizThe University of Texas at Dallas, Richardson, TX 75080-3021, USA.
Iqra QureshiThe University of Texas at Dallas, Richardson, TX 75080-3021, USA.
Patrick D GanzerThe University of Texas at Dallas, Richardson, TX 75080-3021, USA.
Robert L RennakerThe University of Texas at Dallas, Richardson, TX 75080-3021, USA.
Seth A HaysThe University of Texas at Dallas, Richardson, TX 75080-3021, USA seth.hays@utdallas.edu.
The University of Texas at Dallas · USMicroTransponder (United States) · US

Funding

Vagus Nerve Stimulation Paired with Rehabilitative Training to Enhance PlasticityR01NS085167 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI KILGARD, MICHAEL P, RENNAKER, ROBERT L · 2014 to 2018
$1.9M
Evaluation of the Neuromodulatory Mechanisms of Vagus Nerve Stimulation to Improve Motor Rehabilitation after StrokeR01NS094384 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI HAYS, SETH ALANSON · 2016 to 2020
$1.7M
Animal Model of Speech Sound Processing in AutismR01DC010433 · NIDCD · UNIVERSITY OF TEXAS DALLAS · PI KILGARD, MICHAEL P · 2010 to 2014
$1.4M
NIDCD NIH HHS R01 DC010433NINDS NIH HHS R01 NS085167NINDS NIH HHS R01 NS094384
6 · The paper itself

Abstract

BACKGROUND AND

objectiveStroke is a leading cause of long-term disability. Currently, there are no consistently effective rehabilitative treatments for chronic stroke patients. Our recent studies demonstrate that vagus nerve stimulation (VNS) paired with rehabilitative training improves recovery of function in multiple models of stroke. Here, we evaluated the ability of VNS paired with rehabilitative training to improve recovery of forelimb strength when initiated many weeks after a cortical and subcortical ischemic lesion in subjects with stable, chronic motor deficits.

methodsRats were trained to perform an automated, quantitative measure of voluntary forelimb strength. Once proficient, rats received injections of endothelin-1 to cause a unilateral cortical and subcortical ischemic lesion. Then, 6 weeks after the lesion, rats underwent rehabilitative training paired with VNS (Paired VNS; n = 10), rehabilitative training with equivalent VNS delivered 2 hours after daily rehabilitative training (Delayed VNS; n = 10), or rehabilitative training without VNS (Rehab, n = 9).

resultsVNS paired with rehabilitative training significantly improved recovery of forelimb function compared with control groups. The Paired VNS group displayed an 86% recovery of strength, the Rehab group exhibited 47% recovery, and the Delayed VNS group exhibited 42% recovery. Improvement in forelimb function was sustained in the Paired VNS group after the cessation of stimulation, potentially indicating lasting benefits. No differences in intensity of rehabilitative training, lesion size, or MAP-2 expression were observed between groups.

conclusionVNS paired with rehabilitative training confers significantly greater recovery of forelimb function after chronic ischemic stroke in rats.

Indexed as

Stroke RehabilitationTreatment OutcomeAnalysis of VarianceAnimalsBrain IschemiaDisease Models, AnimalFemaleIsometric ContractionPhysical Conditioning, AnimalRatsRats, Sprague-DawleyRecovery of FunctionSeverity of Illness IndexStrokeUpper ExtremityVagus Nerve Stimulationischemic strokerecoveryrehabilitationvagal stimulationvagus nerve

Identifiers

PMID26542082
PMCPMC4854844
OpenAlexW2346928879

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.