ArticleCancer prevention research (Philadelphia, Pa.)2016
Persistence of Bronchial Dysplasia Is Associated with Development of Invasive Squamous Cell Carcinoma.
Article in Cancer prevention research (Philadelphia, Pa.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- A Randomized Phase II Trial of Pioglitazone for Lung Cancer Chemoprevention in High-Risk Current and Former Smokers.Cancer prevention research (Philadelphia, Pa.) · 2019Trial
- Tumor cell plasticity in non-small cell lung cancer: the role of microRNA and implications for diagnosis, prognosis and treatment.Translational cancer research · 2026Review
- Upregulation of an Epithelial miRNA Is Associated with Immune Evasion in Progressive Bronchial Premalignant Lesions.Cancer immunology research · 2026Article
- Extracting Histologic Features to Distinguish Primary and Metastatic Squamous Cell Carcinoma of the Lung.Pathology international · 2026Article
- Real-Time Evolutionary Landscape of the Bronchial Epithelium and Corresponding Dynamic Immune Cell Alterations in Lung Squamous Cell Carcinogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multi-Omics Meets Premalignancy: Paving the Way for Early Prevention of Cancer.Research (Washington, D.C.) · 2025Review
- Premalignant Progression in the Lung: Knowledge Gaps and Novel Opportunities for Interception of Non-Small Cell Lung Cancer. An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2024Review
- Biomarkers in Cancer Screening: Promises and Challenges in Cancer Early Detection.Hematology/oncology clinics of North America · 2024Review
- Article
- Pre-clinical lung squamous cell carcinoma mouse models to identify novel biomarkers and therapeutic interventions.Frontiers in oncology · 2023Review
- Article
- Elevated T cell repertoire diversity is associated with progression of lung squamous cell premalignant lesions.Journal for immunotherapy of cancer · 2021Article
- Aberrant epithelial polarity cues drive the development of precancerous airway lesions.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Spontaneous regression of incidentally diagnosed bronchial squamous cell lung carcinoma after severe bronchitis: A case report.SAGE open medical case reports · 2021Article
- Immune Escape Is an Early Event in Pre-Invasive Lesions of Lung Squamous Cell Carcinoma.Diagnostics (Basel, Switzerland) · 2020Article
- A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention.Cancer prevention research (Philadelphia, Pa.) · 2019Article
- The landscape of early carcinogenesis revealed through the lens of integrative genomics, epigenomics, and transcriptomics.Journal of thoracic disease · 2019Article
- Toward precision medicine based on the molecular landscape of carcinomaJournal of thoracic disease · 2019Article
- Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions.Nature communications · 2019Article
- Prostacyclin and EMT Pathway Markers for Monitoring Response to Lung Cancer Chemoprevention.Cancer prevention research (Philadelphia, Pa.) · 2018Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Bronchial dysplasia (BD), a presumed precursor of pulmonary squamous cell carcinoma (SCC), rarely progresses to invasive cancer. A high-risk cohort at the University of Colorado provided an opportunity to directly sample airway epithelium at mapped sites on successive bronchoscopies. We have hypothesized that persistent dysplastic lesions showing a similar or higher level of dysplasia on follow-up biopsy, are associated with increased risk for the development of SCC. Endoscopic biopsies from 188 high-risk subjects were histologically classified according to the current WHO classification for BD using a numeric histology score ranging from 1 to 8 representing normal bronchial mucosa through invasive lung cancer. Differences in follow-up histology scores were compared between sites classified by clinical, histologic, and immunohistochemical variables. Subjects with a higher frequency of sites that persist or progress to high-grade dysplasia (≥37.5% persist/progress, N = 35 versus <37.5% persist/progress, N = 114) show a significant association with development of incident invasive SCC (adjusted HR, 7.84; 95% confidence interval, 1.56-39.39), and those with incident lung SCC have adjusted mean follow-up histology scores 1.55 U higher than in subjects without lung cancer. Current smoking, elevated Ki67 growth fraction, histologic features of angiogenic squamous dysplasia (ASD) and higher histology score in baseline biopsies are significantly associated with increased follow-up histology scores. These results show that persistent BD is associated with the development of invasive SCC. Furthermore, increased expression of Ki67, the presence of angiogenic change and degree of baseline atypia are associated with persistence of BD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.