ArticleDevelopmental biology2015
En1 directs superior olivary complex neuron positioning, survival, and expression of FoxP1.
Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Spatially varying gene regulation network inference from spatial transcriptomics.Bioinformatics advances · 2026Article
- Pre-Sensory Spontaneous Activity Accelerates Coordinated Maturation of Synaptic Partners and Drives Transition to the Mature Physiological Phenotype.bioRxiv : the preprint server for biology · 2025Article
- Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival.Development (Cambridge, England) · 2024Article
- Identification of Hub Genes and Potential Molecular Pathogenesis in Substantia Nigra in Parkinson's Disease via Bioinformatics Analysis.Parkinson's disease · 2023Article
- Age-Related Hearing Loss: Sensory and Neural Etiology and Their Interdependence.Frontiers in aging neuroscience · 2022Review
- Article
- Glial Cell Expansion Coincides with Neural Circuit Formation in the Developing Auditory Brainstem.Developmental neurobiology · 2018Article
- Talking back: Development of the olivocochlear efferent system.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Nuclear derivatives and axonal projections originating from rhombomere 4 in the mouse hindbrain.Brain structure & function · 2017Article
- Cellular and Molecular Underpinnings of Neuronal Assembly in the Central Auditory System during Mouse Development.Frontiers in neural circuits · 2017Review
- En1 is necessary for survival of neurons in the ventral nuclei of the lateral lemniscus.Developmental neurobiology · 2016Article
- Functional Role of γ-Crystallin N in the Auditory Hindbrain.PloS one · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Little is known about the genetic pathways and transcription factors that control development and maturation of central auditory neurons. En1, a gene expressed by a subset of developing and mature superior olivary complex (SOC) cells, encodes a homeodomain transcription factor important for neuronal development in the midbrain, cerebellum, hindbrain and spinal cord. Using genetic fate-mapping techniques, we show that all En1-lineal cells in the SOC are neurons and that these neurons are glycinergic, cholinergic and GABAergic in neurotransmitter phenotype. En1 deletion does not interfere with specification or neural fate of these cells, but does cause aberrant positioning and subsequent death of all En1-lineal SOC neurons by early postnatal ages. En1-null cells also fail to express the transcription factor FoxP1, suggesting that FoxP1 lies downstream of En1. Our data define important roles for En1 in the development and maturation of a diverse group of brainstem auditory neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.