ArticleDrug and alcohol dependence2015
A comprehensive study of sensorimotor cortex excitability in chronic cocaine users: Integrating TMS and functional MRI data.
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Heightened excitability and impaired Inhibition in methamphetamine users: a pilot study of neurophysiological correlates of psychological symptoms.Psychopharmacology · 2026Article
- Transcranial magnetic stimulation in cocaine use disorder and the risk of seizure: a review of the evidence.Frontiers in psychiatry · 2026Review
- The Effect of 5G Mobile Phone Electromagnetic Exposure on Corticospinal and Intracortical Excitability in Healthy Adults: A Randomized Controlled Pilot Study.Brain sciences · 2025Article
- Harnessing neuroimaging-guided transcranial magnetic stimulation for precision therapy in substance use disorders.Molecular psychiatry · 2025Review
- Left ventromedial prefrontal cortex inhibitory rTMS as an anti-stress intervention in opioid use disorder: Trial design.Contemporary clinical trials communications · 2025Article
- Transcranial Stimulation for the Treatment of Stimulant Use Disorder.Neurology international · 2023Review
- Effects of repetitive transcranial magnetic stimulation and their underlying neural mechanisms evaluated with magnetic resonance imaging-based brain connectivity network analyses.European journal of radiology open · 2023Review
- Finger Tapping Task Activation vs. TMS Hotspot: Different Locations and Networks.Brain topography · 2020Article
- Cocaine Decreases Spontaneous Neuronal Activity and Increases Low-Frequency Neuronal and Hemodynamic Cortical Oscillations.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- rTMS Reduces Psychopathological Burden and Cocaine Consumption in Treatment-Seeking Subjects With Cocaine Use Disorder: An Open Label, Feasibility Study.Frontiers in psychiatry · 2019Article
- The importance of considering polysubstance use: lessons from cocaine research.Drug and alcohol dependence · 2018Review
- Modulating Neural Circuits with Transcranial Magnetic Stimulation: Implications for Addiction Treatment Development.Pharmacological reviews · 2018Review
- Transcranial Magnetic Stimulation of Medial Prefrontal and Cingulate Cortices Reduces Cocaine Self-Administration: A Pilot Study.Frontiers in psychiatry · 2018Article
- Contribution of transcranial magnetic stimulation to assessment of brain connectivity and networks.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017Review
- Brain Stimulation in Addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDisruptions in motor control are often overlooked features of chronic cocaine users. During a simple sensorimotor integration task, for example, cocaine users activate a larger area of cortex than controls but have lower functional connectivity between the cortex and dorsal striatum, which is further correlated with poor performance. The purpose of this study was to determine whether abnormal cortical excitability in cocaine users was related to disrupted inhibitory or excitatory mechanisms, as measured by transcranial magnetic stimulation (TMS).
methodsA battery of TMS measures were acquired from 87 individuals (50 cocaine dependent, 37 controls). Functional MRI data were acquired from a subset of 28 individuals who performed a block-design finger tapping task.
resultsTMS measures revealed that cocaine users had significantly higher resting motor thresholds and higher intracortical cortical facilitation (ICF) than controls. There was no between-group difference in either measure of cortical inhibition. Task-evoked BOLD signal in the motor cortex was significantly correlated with ICF in the cocaine users. There was no significant difference in brain-skull distance between groups.
conclusionThese data demonstrated that cocaine users have disrupted cortical facilitation (as measured with TMS), which is related to elevated BOLD signal. Cortical inhibition, however, is largely intact. Given the relationship between ICF and glutamatergic agents, this may be a potentially fruitful and treatable target in addiction. Finally, among controls the distance from the scalp to the cortex was correlated with the motor threshold which may be a useful parameter to integrate into therapeutic TMS protocols in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.