Evidence map›Paper›PMID 26541738›Full record

Trial reportSurgical endoscopy2016

Dexmedetomidine versus morphine infusion following laparoscopic bariatric surgery: effect on supplemental narcotic requirement during the first 24 h.

Sami Abu-Halaweh, Firas Obeidat, Anthony R Absalom, Abdelkareem AlOweidi, Mahmood Abu Abeeleh, Ibrahim Qudaisat, Fay Robinson, Keira P Mason

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
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  5. Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Sami Abu-HalawehDepartment of Anesthesia and ICU, Faculty of Medicine, University of Jordan and Jordan University Hospital, Amman, Jordan.
Firas ObeidatDepartment of Surgery, Faculty of Medicine, University of Jordan and Jordan University Hospital, Amman, Jordan.
Anthony R AbsalomDepartment of Anesthesia, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Abdelkareem AlOweidiDepartment of Anesthesia and ICU, Faculty of Medicine, University of Jordan and Jordan University Hospital, Amman, Jordan.
Mahmood Abu AbeelehDepartment of Surgery, Faculty of Medicine, University of Jordan and Jordan University Hospital, Amman, Jordan.
Ibrahim QudaisatDepartment of Anesthesia and ICU, Faculty of Medicine, University of Jordan and Jordan University Hospital, Amman, Jordan.
Fay RobinsonStatistical Programmer, DM-Stat, Inc., Malden, MA, USA.
Keira P MasonDepartment of Anesthesia, Perioperative and Pain Medicine, Harvard Medical School, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA, 02115, USA. keira.mason@childrens.harvard.edu.
University of Jordan · JODM-STAT (United States) · USHarvard University · USUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe primary aim of this pilot study was to determine whether the dexmedetomidine infusion initiated immediately after laparoscopic bariatric surgery, offers an advantage over a morphine infusion with respect to rescue morphine and paracetamol requirements over the first 24 post-operative hours.

methodsSixty morbidly obese adult patients scheduled for laparoscopic bariatric surgery were randomly assigned to receive an infusion of either 0.3 mcg/kg/h dexmedetomidine (Group D) or 3 mg/h Morphine (Group M) for 24 h immediately post-operatively. All patients received standardized general anesthesia and were evaluated and treated for pain in the intensive care unit by providers who were blinded to their treatment group. The primary outcome was the need for supplemental, "rescue" paracetamol (Dolargan. Hikma, Jordan) and morphine titrated to achieve visual analog scales (VAS) of <40 and <70, respectively.

resultsA total of 60 patients (77 % female, mean age 33.5 years ± 9.5 and body mass index (BMI) 43.0 ± 4.5) were randomized to Group M and 30 to Group D. There were no significant differences in mean rescue paracetamol and morphine requirements. Mean total morphine requirements in Group D were 6.1 ± 3.1 mg, whereas 72.9 ± 2.2 mg in Group M (p < 0.0001).

conclusionsAn intravenous infusion of dexmedetomidine, initiated and continued for 24 h following laparoscopic bariatric surgery, can decrease the overall morphine requirements during this period. This pilot study demonstrated that the post-operative initiation of dexmedetomidine can be morphine sparing following laparoscopic bariatric surgery.

Indexed as

Bariatric SurgeryLaparoscopyAdolescentAdultAnalgesics, Non-NarcoticAnalgesics, OpioidDexmedetomidineFemaleHumansInfusions, IntravenousMaleMiddle AgedMorphinePilot ProjectsPostoperative PainVisual Analog ScaleAnalgesics, Non-NarcoticAnalgesics, OpioidDexmedetomidineMorphineAdverse eventsQuality and outcomesSedation

Identifiers

PMID26541738
OpenAlexW2238527705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.